动物造模 z-bio 2022-09-13 279

　　Objective: To investigate the detection method of penile somatosensory evoked potentials in beagle dogs under general anesthesia and the changes of somatosensory evoked potentials in the process of dorsal penile nerve resection, so as to provide reference for further research.

　　Methods: The somatosensory evoked potentials of the glans penis and the dorsal penile nerve were detected during dorsal penile nerve resection under general anesthesia in 5 beagle dogs, and the waveforms and parameter values were observed.

　　Results: Under general anesthesia, relatively stable GPSEP and DNSEP waveforms of beagle dogs could be obtained. The average latency of GPSEP in 5 beagle dogs under general anesthesia was (41.84±1.41) ms, and the average amplitude was (1.56±0.26) μV; the average latency of DNSEP was (33.46±2.45)ms, the average amplitude was (1.80±0.52)μV. During the process of dorsal penile nerve resection in Beagle dogs, the latency of DNSEP and GPSEP changed, and the difference was significant (P<0.05).

　　Conclusion: The detection of penile somatosensory evoked potentials under general anesthesia is feasible and the waveform is relatively stable; DNSEP and GPSEP latency may change during the process of dorsal penile nerve resection, which is expected to provide experimental animal basis for further research.