动物造模,高脂血症食蟹猴模型 z-bio 2022-09-13 406

　　Objective: To establish a hyperlipidemia cynomolgus monkey model with similar characteristics of human diseases, and to provide an ideal animal model for the development of lipid-lowering drugs (especially biological lipid-lowering drugs).

　　METHODS: Male cynomolgus monkeys in the treatment group were given the optimized and stereotyped semi-liquid high-sugar and high-fat dietary emulsion by intranasal feeding for 6 days a week, and the monkeys' body weight (BW), body mass index (BMI), and serum total cholesterol were monitored regularly. (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDL-C) and other indicators, and the change trend of their blood lipid indicators was analyzed.

　　Results: Compared with the corresponding control group, all 6 middle-aged and elderly male cynomolgus monkeys and 5 adult male cynomolgus monkeys in the treatment group were successfully modeled until the 3rd month of modeling, and all the treatments were completed until the 21st month after modeling. The male cynomolgus monkeys in the group still maintained higher blood lipid levels.

　　CONCLUSION: The cynomolgus monkey model of hyperlipidemia can be successfully prepared by quantitative feeding of semi-liquid high-sugar and high-fat dietary emulsion for 3 consecutive months. Study on the pathogenesis of hyperlipidemia and evaluation of drug preclinical efficacy.