动物造模,荷子宫肌瘤组织移植瘤模型 z-bio 2022-09-16 356

　　OBJECTIVE: To establish a rat model of uterine fibroids-bearing tissue transplanted by tissue transplantation in immunosuppressive rats, and to provide a new animal model for the study of uterine fibroids.

　　Methods: Two weeks before the operation, the rats were given the immunosuppressant mycophenolate mofetil by gavage and continued until the end of the experiment? Twenty Wistar rats were randomly divided into 4 groups, according to the different hormones supplemented after intraperitoneal transplantation They were group A (fenmetone), group B (estradiol), group C (Daphton), and group D (control group). The samples were collected 4 weeks after operation, and the morphology and histomorphology of fibroids were observed.

　　Result: The success rate of modeling in group A was 90%, that in group B was 40%, and the success rate of modeling in group C and group D was 0?

　　Conclusion: The rat model of uterine fibroids transplanted tumor has high success rate and low cost, and can be used as a new animal model for the study of uterine fibroids transplanted tumor?