动物造模,慢性心肌缺血小型猪模型 z-bio 2022-09-20 424

　　Objective: To investigate the feasibility of a series of methods for treating chronic myocardial ischemia in miniature pigs with an Ameroid constriction ring placed in the left anterior descending artery with embedded needles.

　　Methods: A miniature pig model of chronic myocardial ischemia was established by placing an Ameroid constriction ring in the left anterior descending branch of the left coronary artery in Bama miniature pigs. " point ), respectively bury acupuncture at "Neiguan" and "Zusanli" points and electro-acupuncture, and take the material after 6 weeks?

　　Results: Postoperative gross pathology showed that the ischemic area appeared in both groups, and the ischemic area of acupuncture at "Zusanli" was larger than that at "Neiguan". The ultrastructure of myocardial cells showed mitochondrial vacuolization and fibrosis in both groups. ?

　　Conclusion: Acupuncture at the "Neiguan" point of the pericardium meridian can protect the myocardium by reducing myocardial ischemia, but it cannot inhibit the existing myocardial ischemia injury? Is it feasible to use a swine chronic myocardial ischemia model for experimental animals and to use embedded needles for treatment?