动物造模,妊娠糖尿病大鼠模型 z-bio 2022-10-18 346

　　Objective to systematically evaluate the effects of placenta differentially expressed proteins on the growth and development of placenta in diabetes of pregnancy (GDM) rat model.

　　Methods The databases of PubMed, Web of Science, EMBase, Cochrane Library, Ovid/LWW, Scopus, CNKI, Wanfang, Vip and Chinese biomedical literature were retrieved by computer, and the relevant references were manually retrieved. The retrieval time was up to September 30, 2020; In the included literature, two researchers independently performed literature screening, data extraction, quality evaluation and result analysis.

　　Results Totally 16 articles were included; The results showed that: (1) placental differentially expressed proteins affected the proliferation and apoptosis of placental trophoblasts in GDM rats, interfered with placental angiogenesis, increased vascular permeability, enhanced placental oxidative stress and inflammatory reaction, and caused placental growth and development abnormalities in GDM rats; (2) The placental differentially expressed proteins were mainly located in the cytoplasm and/or nucleus of spongy trophoblasts, labyrinthine trophoblasts, giant cells and fetal endothelial cells of GDM rat placenta; (3) The placentas of GDM rats had increased trophoblast area, decreased blood vessel density and tissue structure disorder.

　　Conclusion The differential expression of placental protein may cause abnormal growth and development of placentas in GDM rats by changing placental structure and function, thus promoting or aggravating the occurrence of GDM and its complications. However, due to the limitations of the included study in terms of the preciseness of experimental design and internal authenticity, it still needs to be further verified by a large number of high-quality studies.