动物造模,高血脂症 z-bio 2022-10-19 247

　　Objective This study is the first to evaluate the lipid-lowering effect of adding citrus polymethoxyflavone powder to biscuits in hyperlipidemia mouse model through the measurement of lipid metabolism experimental indicators, in order to provide a basis for developing a new type of functional food.

　　Methods 60 male KM mice were randomly divided into 6 groups. They were fed continuously for 6 weeks to establish the model of hyperlipidemia mice. Then they were fed with corresponding biscuits. After 6 weeks of continuous feeding, the body weight, Lee's index, organ changes, liver tissue biochemical indicators and serum lipid content of the mice were measured.

　　Results After 6 weeks, the body weight, Lee's index, organ changes, liver biochemical indexes and blood lipid content in serum of mice all showed that the polymethoxyflavone biscuit could inhibit the growth of body weight of hyperlipidemic mice, reduce the Lee's index of hyperlipidemic mice, and improve the abnormal lipid metabolism of common biochemical indexes in serum of hyperlipidemic mice.

　　Conclusion Polymethoxy flavone biscuit can obviously improve the abnormal lipid metabolism of common biochemical indexes in serum of hyperlipidemia model mice. The effect of lipid-lowering biscuits on blood lipids in mice: lipid-lowering biscuits have obvious effects on triglycerides (TG), no significant effects on high-density lipoprotein (HDL-C), and more obvious effects on low-density lipoprotein (LDL-C). It may play a role in the treatment or health care of dyslipidemia, fatty liver and other related diseases caused by dyslipidemia