动物造模,血管性认知障碍动物模型 z-bio 2022-10-31 393

　　Vascular cognitive impairment is one of the hot spots in medical research in recent years. The etiology of this disease is complex, and its clinical manifestations include multiple cognitive domain disorders, memory impairment, and dementia, which seriously affect the quality of life of patients. The successful establishment of an animal model of chronic cerebral ischemic vascular cognitive impairment is the first step for medical research on its pathogenesis, providing treatment and tackling the disease.

　　After development, there are many animal modeling methods for VCI, most of which are rodents. For rats, there are four vessel occlusion (4-VO) method, improved 4-VO method, three-stage 4-VO method, 2-vessel occlusion (2-VO) method, improved 2-VO method, and modified common carotid artery stenosis (mCCAO) method; For mice with bilateral CCA stenosis (BCAS) and asymmetric CCA surgery (ACAS), etc. According to the different surgical modeling methods used, there are certain differences in the pathological damage location, damage degree, survival rate, and animal behavior of animals after surgery.

　　This article will systematically review the surgical construction methods, phenotypes, evaluation indicators, advantages and disadvantages of vascular dementia models of the above eight rodent rodents, hoping to provide some guidance and help for researchers in the selection of relevant animal models.