动物造模,颅骨缺损动物模型 z-bio 2022-11-01 345

　　Objective To explore the ideal method of constructing rat skull defect model and improve the success rate of bone defect animal model.

　　Methods Forty adult male SD rats were randomly divided into the control group and the experimental group. The control group used the traditional method of skull defect model surgery, and only used the hollow ring drill to drill the full skull defect perpendicular to the surface of the skull; The experimental group used improved surgical methods, hollow and solid drill bits, and changed the force direction of the drill bit at different stages of the skull drilling process. The operation drilling time of the two groups of models was compared, and whether there were periosteum, dura mater, brain tissue injury, bleeding and other complications during the operation. At 8 weeks after the operation, observe whether the implanted alumina bioceramic materials in the two groups of models have displacement, looseness and bone bonding, and compare the success rate of the two groups of modeling.

　　Results Compared with the control group, the drilling time in the experimental group was significantly shortened (P<0.01), and the complications such as periosteum, dura mater, brain tissue injury and hemorrhage were significantly reduced (P<0.05). There was no displacement and looseness of alumina bioceramic materials after operation (P<0.05). The materials were well combined with the skull, and the success rate of modeling was significantly increased (P<0.05).

　　Conclusion The improved method of constructing rat skull defect model has the advantages of short drilling time and fewer complications, which can greatly improve the success rate of modeling, and can effectively evaluate the bone repair performance of orthopedic implants in vivo.