动物造模,小型猪肥胖模型 z-bio 2022-11-02 240

　　Objective To investigate the effect of high fat and high sugar diet on fat distribution and blood biochemical indexes in Bama miniature pigs.

　　Methods 14 Bama mini pigs and 8 experimental pigs were fed with high-fat and high-sugar diet for 30 weeks. They were type 2 diabetes susceptible mini pigs bred in our laboratory; The control group was fed with normal diet. After 30 weeks, the body shape coefficient, CT scanning fat content, blood collection and biochemical indicators were measured to compare the differences between the experimental group and the control group.

　　Results There were significant differences in body mass, body mass index (BMI), total fat content and visceral fat content between the experimental group and the control group after 30 weeks of high fat and high sugar diet (P<0.05); The blood biochemical indexes of insulin, total cholesterol, high density lipoprotein cholesterol and triglyceride were significantly different from those of the control group (P<0.01), and low density lipoprotein cholesterol was significantly different from those of the control group (P<0.05). In addition, there were significant differences in serum protein and creatinine between the experimental group and the control group (P<0.05); Uric acid and urea were significantly different from those in the control group (P<0.01), indicating that kidney damage was present in the experimental group.

　　Conclusion High fat and high sugar diet can cause fat accumulation in Bama miniature pigs, especially visceral fat accumulation. The blood biochemical indicators are hyperlipidemia with renal function damage.