动物造模,高脂血症食蟹猴模型 z-bio 2022-11-03 284

　　Objective: To establish a hyperlipidemic cynomolgus monkey model similar to human disease characteristics, and provide an ideal animal model for the research and development of lipid-lowering drugs (especially biological lipid-lowering drugs)

　　Methods: The optimized and finalized semi liquid high sugar and high fat dietary emulsion was given to the male cynomolgus monkeys of the treatment group by nasal feeding 6 days a week. The monkey body weight (BW), body mass index (BMI), serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDL-C) and other indicators were monitored regularly to analyze the change trend of their blood lipid indicators

　　Results: Compared with the corresponding control group, by the third month of modeling, 6 middle-aged and old male cynomolgus monkeys and 5 adult male cynomolgus monkeys in the treatment group had been successfully modeled, and by the 21st month of modeling, the male cynomolgus monkeys in all treatment groups remained at a higher level of blood lipids

　　Conclusion: The model of hyperlipidemia cynomolgus monkey can be successfully prepared by quantitative feeding of semi liquid high sugar and high fat dietary emulsion for three months. The model has the characteristics of hypercholesterolemia and high and low density lipoprotein cholesterol, and can be used to study the pathogenesis of hyperlipidemia and to evaluate the efficacy of drugs before clinical use