动物造模 z-bio 2022-11-03 231

　　Objective: To investigate the relationship between the establishment of tree shrew gallstone model by feeding tree shrews with high cholesterol diet and substance P

　　Methods: The tree shrew gallstone model was established to detect the SP immunohistochemical expression in the digestive tract, and the model group was compared with the control group

　　Results: Compared with the control group, the content of SP immunohistochemical expression in the digestive tract of tree shrews in the model group was lower than that in the control group (P<0.05). The tree shrews gallstone model was negatively correlated with the level of SP expression

　　Conclusion: Cholecystolithiasis of tree shrews is related to the regulatory mechanism of digestive tract secretion hormones