动物造模,大脑中动脉栓塞模型 z-bio 2022-11-23 340

　　Objective: To compare the effectiveness, success rate and mortality of middle cerebral artery embolization models in rats made by common carotid artery puncture and traditional thread embolism methods.

　　Methods: Thirty two male rats were randomly divided into the common carotid artery puncture group and the traditional thread embolism group. The thread embolism was inserted from the common carotid artery to embolize the middle cerebral artery. Bederson neural function scoring standard was used to score the neurological function 24 hours after operation, and the success rate and mortality rate of 24 hours were counted.

　　Results: The insertion time, success rate and mortality of MCAO models prepared by common carotid artery puncture and traditional surgical methods were (82.3 ± 17.4) s and (164.6 ± 22.0) s, respectively (P<0.01); and="" there="" was="" no="" significant="" difference="" p="">0.05); There was no significant difference between 6.25% and 18.75% (P>0.05).

　　Conclusion: The method of common carotid artery puncture is simple, time-saving, minimally invasive, and highly operable.