OBJECTIVE: To investigate the effects of aluminum phosphate gel and phaseolin solution on the esophageal structure and IL-8 and PGE2 content of rats with lysolecithin-related reflux esophagitis and its possible mechanism.

　　Method: 60 SD rats were randomly divided into aluminum phosphate group (n = 10), rehabilitation group (n = 10), aluminum phosphate + rehabilitation group (n = 10), model group (n = 20). Divided into a control group (n = 10), the esophagus was perfused with 1.5 mg/L lysolecithin + 0.1 mol/L HCI (containing 0.5% pepsin) to prepare a lysolecithin-related reflux esophagitis model, and the control group was perfused Liquid etc. Normal saline was measured for 14 days, 10 model rats and all control rats were sacrificed, and the intact esophagus was removed. The remaining 4 groups of rats were perfused with aluminum phosphate gel, canfuxin solution, aluminum phosphate gel + canfuxin solution and normal saline through the esophagus for 14 days. All rats were sacrificed and the entire esophagus was removed. Commonly used morphology, esophageal ultramicromorphology and radioimmunoassay to detect IL-8 and PGE2 levels.

　　Results: At the end of the model preparation, the histomorphological comparison between the model group and the control group: the common morphology of the model group is the infiltration of mucosa and submucosa with a large number of inflammatory cells, vacuole degeneration, erosion, and even epithelial cell ulcers and ultrastructure change. The mucosal epithelial cells fell off into large pieces, and the morphology and ultrastructure of the control group were normal. Comparison with the treatment group and the model group at the end of treatment: the general morphology and ultrastructure of the esophagus in each treatment group showed mild mucosal damage, the mucosal damage index, and the levels of IL-8 and PGE2 in esophageal tissue were lower than those of the model group ( P \u003c0.05). Comparison of aluminum phosphate + canfuxin group with aluminum phosphate group and canfuxin group: the general morphology and ultrastructure of esophageal tissue is that the degree of mucosal damage is light, the mucosal damage index, IL-8 and PGE 2 content are all lower (P \u003c0.05 ).

　　Conclusion: Canfuxin liquid and aluminum phosphate gel have a protective effect on the esophagus tissue of reflux esophagitis model rats caused by mixed injection of lysolecithin and hydrochloric acid. This mechanism may be related to the reduction and prevention of IL-8 and PGE2 levels. Inflammation is related to development. Lysolecithin and hydrochloric acid act as a mixed reflux of duodenal gastroesophageal reflux, causing GERD. The pathogenic mechanism may be related to the up-regulation of IL-8 and PGE2 levels in esophageal tissue.