上海生科院,胰岛素敏感性,动物实验 z-bo 2020-08-24 587

　　The international academic journal "Diabetes" has published online research papers by Guo Feifan's research group from the Institute of Nutrition Science, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences. In this study, liver FOG2 played a key role in regulating insulin sensitivity and liver lipid metabolism by affecting the expression of PPARα, providing new theories and ideas for the etiology and treatment of type 2 diabetes and fatty liver. I found it was provided. In recent years, due to changes in lifestyle and eating habits, the incidence of type 2 diabetes and non-alcoholic fatty liver has increased year by year. resulting in. , Which seriously endangers human life and health. Insulin resistance is an important pathological feature of type 2 diabetes, and insulin resistance has nothing to do with abnormal lipid metabolism. At present, the specific molecular mechanism of insulin resistance is unclear. As an important transcription regulator, FOG2 plays a biologically important role in angiogenesis and development, but its role in insulin sensitivity and fatty liver has not been reported.

　　Guo Feifan’s research team found that FOG2 expression was significantly up-regulated in the liver of db/db mice (insulin resistance model). Injecting FOG2 into db/db mice by tail vein injection of adenovirus can significantly relax the mice. Injecting insulin resistance in wild-type mice to improve insulin sensitivity and overexpression of FOG2 adenovirus can significantly reduce the insulin sensitivity of mice. Further studies have shown that overexpression of FOG2 can significantly reduce the accumulation of liver lipids, while reducing FOG2 in wild-type mice can cause significant accumulation of liver lipids. I will. The detailed mechanism study shows that FOG2 is mediated by NR2F2. R2F2 affects the expression of PPARα in mice and affects insulin sensitivity and liver lipid metabolism.

　　This study proved that FOG2 plays an important role in regulating insulin sensitivity and lipid metabolism, deepening the etiology of type 2 diabetes and fatty liver, and the treatment of type 2 diabetes and fatty liver. Provide the goals of the following drugs:

　　This research work was supported by the National Natural Science Foundation of China, the Ministry of Science and Technology and the Chinese Academy of Sciences. Professor Liu Yong of Wuhan University also provided support.