动物实验,精氨酸抗利尿激素 z-bo 2020-08-24 585

　　Objective: To investigate the effect of arginine antidiuretic hormone (AVP) on clearing pulmonary edema fluid in acute lung injury.

　　Method: 48 healthy adult male SD rats were randomly divided into control group, model group (ALI group) and AVP group, the pathological morphology, lung water content, alveolar epithelial permeability and alveolar of each group. Liquid is observed. Measure clearance rate (AFC), alveolar epithelial sodium channel (ENaC) and changes in the expression of sodium/potassium ATPase (Na +, K + -ATPase).

　　Results: After AVP treatment, the alveolar epithelial permeability of the model group decreased (0.27±0.15 vs. 0.59±0.19), lung water content (5.01±1.59 vs. 8.67±1.79), and AFC increased (23.56±4.51 vs. 8. 28±3.57) ), α-ENaC (1.296±0.322 vs 0.349±0.141) and α1-Na+, K + -ATPase expression increased (1.421±0.389 vs 0.338±0.186), the difference was significant. Yes (P\u003c0.05).

　　Conclusion: AVP can promote AFC, and its mode of action can be achieved by up-regulating α-ENaC and α1-Na+, K + -ATPase channel proteins.