动物实验,麻醉剂 z-bo 2020-08-26 477

　　Glo The Globe and Mail reported that pre-clinical data published in the Journal of Clinical Research can cause long-term cognitive impairment after anesthesia or even after drug withdrawal. The researchers injected a certain dose of anesthetic into the mice to calm them instead of unconscious. The exposure time to anesthetics was very short, but the mice developed cognitive impairment for at least one week. The co-author author said: "I don't know what this means for patients. He pointed out that a week is very long."

　　Orser said that the memory receptors in the hippocampus of the brain are "very sensitive to drugs," she added. "One hypothesis we have been trying to prove is that once the drug fails, the function of these receptors will return to normal...but there is no Meet the required clinical conditions."

　　At present, illness, inflammation, opioids, stress, lack of sleep during postoperative recovery. Known to cause postoperative cognitive impairment. The author wrote: In addition, these drugs that achieve the predetermined goals are one of the criminals that cause memory loss. "

　　Scientists are looking for different ways to reduce the potential cognitive side effects caused by general anesthesia. Orser pointed out that dexmedetomidine acts on a different type of receptor than drugs commonly used for general anesthesia, and the study found that the drug does not cause long-term memory loss. Medetomidine is not an effective anesthetic, but "sedatives can be reduced" because sedatives may be sufficient or used at the same time as general anesthesia.