动物实验,尿通卡克乃其片,毒性实验 z-bo 2020-08-26 554

　　Objective: To study the changes of hematological indicators in the long-term toxicity test of Xuetong Kaganaiqi tablets.

　　Method: 120 SD rats (half male and half male) were randomly divided into Niaotong Ka Kneeqi tablets control group, low, medium and high dose groups. The control group was given 0.5% sodium carboxymethylcellulose suspension in the stomach, and the low, medium and high dose groups were given 0.32 g, 1.6 g and 3.2 g (crude drug)/kg·d at the 6th week. After stopping the drug, the general condition of the rats, blood cell changes, blood biochemical changes, electrolytes and coagulation indexes were observed every day for 180 days, 90 days, 180 days and 30 days.

　　Result: During the experiment, the rats did not die and there was no obvious toxicity. Compared with the control group, the rat red blood cell count (RBC), hemoglobin (HGB), average red blood cell hemoglobin content (MCH), average red blood cell hemoglobin concentration (MCHC), platelet count (PLT), white blood cell count (WBC) during the experiment period, Lymphocyte percentage (LYMP%); alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), glucose (GLU), urea nitrogen (BUN), white protein (ALB), total bilirubin (TBIL), creatinine (Crea), total cholesterol (TCHO), triglycerides (TG), creatine phosphokinase (CK); potassium ion concentration (K +), sodium ion concentration (Na +), chloride ion concentration (Cl- ), prothrombin time (PT) are statistically different (P\u003c0.05? P\u003c0.01), but there is no regularity of time and dose, and no disease The meaning of science.

　　Conclusion: The dosage of tongtongkanaiqi tablet cornstarch is 0.32g, 1.6g, 3.2g (herbal medicine)/kg? d. There is no obvious abnormality in the blood indexes of rats. This drug has been used in clinical doses for a long time.