动物实验,卵巢 z-bo 2020-08-26 424

　　Ovary may be the secret to preventing female aging. Replacing the ovaries of old mice with ovaries of young mice seems to reverse the aging effects of the immune and metabolic systems of female mice and extend their lifespan. Will people get the same benefits?

　　With age, the body's metabolism slows down and the immune system is exhausted. Older people are more likely to develop severe cold and flu symptoms. This may be because there are few live immune cells. A slow metabolic system means that glucose stays in the blood for longer after a meal. Over time, high blood sugar can damage human organs. However, experiments on mice have shown that organ transplants in young mice can reverse this change. Jeffrey Mason of the University of Utah removed the ovaries from 10 mice that stopped producing estrogen (this transition period corresponds to menopause) and replaced them with 60-day-old mice (about 20 mice ). .. Rat ovary at the beginning of the year. Four months later, Mason evaluated the immune systems of these mice. The number of immune cells (naive T cells) that respond to new infections will decrease with age, and the naive T cells of these mice will decrease before surgery. At 6 months (before surgery) and 16 months, the initial number of T cells in these mice increased by approximately 67%. During the same period, the number of relevant cells in untreated mice decreased by 80%. To verify the metabolic mechanism, Mason injected the mice with glucose and tested the time required for blood sugar to return to normal. Mason announced that mice with younger ovaries can clear blood glucose faster than mice without surgery. Announce an announcement.

　　This discovery is based on the team’s previous work. Their research showed that the survival time of mice transplanted with young ovaries was about 40% longer than that of mice of the same age, and their hearts were healthy. Mason said: "This changes the current perception of the role of the ovaries in the aging process."