动物实验 z-bo 2020-08-27 475

　　The research team of Research Kageshiro Kawa, a physics researcher at the Institute of Physics and Chemistry in Japan, has developed an effective method to induce low-metabolism "sleep" through experiments in mice.

　　When hibernating animals (such as squirrels and bears) enter a low metabolic state during hibernation, their basal metabolism drops from normal 1% to 25%, and I can survive winter hunger by reducing energy consumption. After waking up from sleep, you can start normal activities. Being able to "hibernate" humans and human organs can solve current problems, which are difficult to achieve for long-term preservation of regenerated organs and transportation of critically ill patients. There is evidence that primates can also hibernate, but scientists currently do not understand the mechanism of hibernation. In a new study, scientists discovered that the mechanism of hibernation is the same as the metabolic control mechanism of hibernation. They have developed a stable dormancy induction method. The biggest problem in inducing mice to dormancy is the change of individual dormancy performance, and it is difficult to give a definition of dormancy. The research team measured the changes in oxygen consumption and body temperature of each mouse, and based on this, established a mathematical model to induce dormancy by controlling temperature and restricting eating. It was found that there is a 100% chance of inducing dormancy in the range of 12 to 24 degrees Celsius. According to research, when the set temperature remains unchanged, the actual body temperature of dormant mice is similar to that of hibernating animals, and the metabolism will also decrease. Active low metabolism is a survival skill acquired by mammals through long-term evolution. Related research is very important for regenerative medicine and emergency medicine.