动物实验 z-bo 2020-08-27 523

　　Professor Jenny Tung of Duke University in the United States published a "scientific" study that low social status can damage the immune system of animals. This may help explain why people at the bottom of society are more likely to suffer from chronic inflammatory diseases, such as heart disease and diabetes. The level of social status affects people's health and life span, and people living at the bottom of society are more likely to get sick.

　　In order to study how social status affects health, Jenny Tan's team selected female monkeys from the Yarkes National Primate Research Center for research. Forty-five unrelated female macaques were randomly divided into five groups, and new macaques were added to the group each time to promote the formation of social class. The monkeys who joined the group before tended to have a higher social status. Researchers observed macaques and combined with genomics to assess the impact of social status on immune function.

　　The monkeys with the lowest social level are more likely to be harassed by their peers and have less contact with them. After analyzing the blood samples of macaques, the researchers found that the proportion of immune cells in the circulatory system of macaques with low social status was abnormal, and more than 1,600 immune-related genes were differentially expressed in these cells. I found. Infecting immune cells with bacterial toxins will cause lower-grade monkeys to produce a stronger immune response to bacteria, thereby making the immune system more "exciting" and mediated by the intracellular Tlr-4 signaling pathway. It stimulates chronic diseases. inflammation. Later, scientists adjusted a group of rhesus monkeys and found that elevated levels would reduce the immune function of some monkeys. Stanford University professor Robert Sapolsky believes that humans and non-human primates in the collective land category are similar, and the findings are applicable to humans. In addition to poor lifestyle and psychological factors, pressure caused by various social statuses may be another important factor in determining body length.