动物实验,肠道菌群 z-bo 2020-08-27 571

　　Individuals respond differently to the intestinal flora of diet intervention, and the spread of diet-responsive bacterial populations between hosts can enhance their subsequent response to diet.

　　When you try to improve your diet in the new year, the intestinal flora may not meet your expectations. In a study published by the University of Washington in CellHost & Microbe on November 29, researchers found that when mice change from an uncontrolled American diet to a healthy, calorie-restricted plant-based diet, they will soon have a New diet. I investigated why it was not completed and succeeded. They found that certain gut bacteria may need to be modified to implement a new diet plan as soon as possible. Washington University

　　St. Jeffrey Gordon, Director of Louis’ Center for Genome Science and Systems Biology, said: “If you want to develop a diet plan that improves someone’s health, it’s important to understand which microorganisms will interfere with your new plan. The beneficial effects.” We explored different people Intestinal microflora. And found a way to identify microorganisms that help promote a healthy diet.

　　How people’s diet affects the human intestinal flora. In order to study how the microbiota adapts to new eating habits, Gordon et al. first started with people who follow calorie restriction and fortification. Researchers have found that those who follow a typical, unrestricted Meyer diet, a plant-rich, low-calorie diet, have a more diverse microbial community. Then, the researchers transplanted gut microbes from various donors into a group of sterile mice, and fed the animals according to the dietary standards of the gut microbe donors or other diet plans. Although each group of mice responded to the new diet, the group of mice transplanted with microbiota under the American diet had a weaker response to a plant-rich diet. In order to determine the microorganisms that can enhance the responsiveness of the microbial community in the American diet, the researchers established a series of step-by-step contact experiments between mice. After cohabiting transplanted mice and long-term consumption of various human microorganisms rich in plant-based diets, the microorganisms may enter the diet under the mythical diet based on the plant-based diet. Facts have proved that the microbial community can greatly improve the response of plants to diet. We call it a demographic group. "The lead author Nicholas Griffin, a lecturer at Washington University in St. Louis, said. "People with uncontrolled diets lack bacteria, which initially migrated to the microbial community under the American diet.

　　Researchers have found that their findings help people develop new dietary strategies. They also emphasized that more research is needed to improve the effectiveness of prescribed healthy diets. This optimistic diet can help people, but it is necessary to determine the factors of microbial exchange between people. Gordon said: "How do they affect the nutrition of consumers' microbial communities? People are increasingly interested in value and dietary effects. The identification methods described in this study provide hope that microbes will become the next generation of probiotics, but at the same time, we The microbes investigated will trigger another way of thinking about how humans interact as members of a larger population. We provide them to humans.