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Gene editing methods for establishing animal models mainly include transgene and gene targeting...
2020-11-30Parkinson’s disease is the world’s second largest neurodegenerative disease after Alzheimer’s, posing a serious threat to the health of middle-aged and elderly people...
2020-11-30With the popular ice bucket challenge this summer, gradual freezing syndrome (ALS, amyotrophic lateral sclerosis) has attracted widespread public attention...
2020-11-30The two human HCV receptors CD81 and OCLN were expressed in the liver of ICR mice using transgenic methods...
2020-11-30Recently, in a research paper published in the international journal PLoS Pathogens, staff from the National Institute of Allergy and Infectious Diseases developed for the first time an animal model that can simulate the symptoms of Middle East Respi...
2020-11-30In terms of cognitive ability research, researchers have made great progress using animal experiments. The next step is to build a rodent model that can be used for drug development...
2020-11-30
Immunohistochemical staining showed that the expression of autophagy-related protein Beclin-1 in hippocampal CA1 area decreased after wortmannin, an autophagy inhibitor, interfered with vascular dementia model rats...
2020-11-30In a laboratory in Baltimore, USA, there is a scene where a hairless mouse is placed in rows of plastic boxes, and a yellow card is attached to each box. In fact, each mouse corresponds to a patient who is fighting cancer. These mice are the embodime...
2020-11-30Recently, researchers at the University of Liverpool have successfully constructed a worm model of an incurable and fatal neurodegenerative disease, and used this worm model to screen a potential compound that can treat the disease...
2020-11-30
A research team led by Dr. Nadia Carlesso, associate professor of pediatrics at Indiana University, found that, like a series of fallen dominoes, a series of molecular events in the bone marrow can produce high levels of inflammation, which can disru...
2020-11-30
Researchers at Stanford University School of Medicine in the United States found that squamous type 1 alveolar cells (AT1 cells) and cuboid type 2 alveolar cells (AT2 cells) developed from a kind of \\\"dual potential\\\" progenitor cells. ...
2020-11-30
A research team led by Zhou Qi, a researcher at the Institute of Zoology, Chinese Academy of Sciences, used CRISPR/Cas9 technology to obtain vWF knockout pigs for the first time, thereby establishing a miniature pig model of von Willebrand disease...
2020-11-30In recent years, mutations in two metabolic enzymes, isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 (IDH1 and IDH2), have been determined to be present in approximately 20% of acute myeloid leukemia (AML)...
2020-11-30Damage to fully developed nerve cells can have irreversible consequences, because once nerve fibers mature, they lose their ability to regenerate. New experiments show that activating a part of the nerve cell regeneration mechanism, a protein called ...
2020-11-27Observe the pathogenesis and pathological characteristics of spontaneous hind limb paralysis rats in the hyperlipidemia susceptible (WSHc) rat population, and preliminary study its pathogenesis, and explore its application and scientific research val...
2020-11-27By feeding astragalus polysaccharides on the growth performance, blood physiology and biochemistry and the incidence of diarrhea in reproductive macaques, research the application of astragalus polysaccharides in the feeding and management of laborat...
2020-11-27