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CAR-T cell therapy edited with CRISPR-Cas9 can be used to treat refractory cancer

CAR-T cell therapy edited with CRISPR-Cas9 can be used to treat refractory cancer

According to the latest data released by researchers at the Abramson Cancer Center of the University of Pennsylvania, CAR-T cells that have undergone Crispr-Cas9 gene editing can persist in cancer patients for several months, and can stably prolifera...

2020-09-30
CRISPR gene-edited CAR-T cells are safe for cancer patients

CRISPR gene-edited CAR-T cells are safe for cancer patients

In a new study, researchers from the University of Pennsylvania and Stanford University combined two state-of-the-art methods-CRISPR (DNA editing) and T cell therapy (using immune system sentinels to destroy tumors)...

2020-09-30
Clinical trials show that gene therapy of hematopoietic stem cells is expected to treat X-chain chronic granulomatous disease

Clinical trials show that gene therapy of hematopoietic stem cells is expected to treat X-chain chronic granulomatous disease

X-chain chronic granulomatous disease (X-chain chronic granulomatous disease, X-CGD) is a rare inherited blood disease...

2020-09-30
Revealing death receptor signaling is essential for CAR-T cell therapy

Revealing death receptor signaling is essential for CAR-T cell therapy

Clarifying death receptor signaling is essential for CAR-T cell therapy\\nScientists have found ways to enhance CAR-T cell therapy...

2020-09-30
How do scientists target stem cells to treat a variety of human cancers?

How do scientists target stem cells to treat a variety of human cancers?

Demystifying the key role of stem cells in lethal gastric cancer...

2020-09-30
RNA vaccine makes claudin-CAR-T cells more effective against solid tumors

RNA vaccine makes claudin-CAR-T cells more effective against solid tumors

Genetically modified T cells (CAR-T) expressing chimeric antigen receptor (CAR) have been clinically successful in adoptive T cell therapy in B cell malignancies...

2020-09-30
Scientists reveal the mechanism of CAR-T cells triggering cytokine release syndrome

Scientists reveal the mechanism of CAR-T cells triggering cytokine release syndrome

The clinical application of transgenic T cells (CAR-T cells) expressing chimeric antigen receptors (CAR) in the treatment of B-cell malignancies has been successful, but cytokine release syndrome (CRS) prevents this situation...

2020-09-30
Reveals that GDNF determines the fate of neural progenitor cells transplanted in vivo and is expected to treat spinal cord injury

Reveals that GDNF determines the fate of neural progenitor cells transplanted in vivo and is expected to treat spinal cord injury

Neural progenitor cells (NPC) are a potential treatment for repairing and regenerating neurons after spinal cord injury. However, after NPC is transplanted into rodents, the harmful microenvironment of the damaged spinal cord leads to limited recover...

2020-09-30
NIH launches clinical trials of autologous stem cells to treat AMD

NIH launches clinical trials of autologous stem cells to treat AMD

Researchers from the National Eye Institute (NEI) are conducting clinical trials to evaluate the clinical safety of the new treatment based on patients’ autologous stem cells for the treatment of geographic atrophy...

2020-09-30
Using human-induced pluripotent stem cells to fight diabetes has great potential

Using human-induced pluripotent stem cells to fight diabetes has great potential

Diabetes is gradually becoming one of the biggest health challenges of our time. According to statistics from the World Health Organization (WHO), one in ten people suffers from diabetes. According to the latest public data, the disease caused 1.6 mi...

2020-09-30
The application prospect of human neural stem cells in the treatment of Alzheimer\'s disease

The application prospect of human neural stem cells in the treatment of Alzheimer's disease

Alzheimer\'s disease (Alzheimer\'s disease, AD) is a progressive neurodegenerative disease, the typical clinical symptoms are cognitive dysfunction, even loss...

2020-09-30
Recurrent mantle cell lymphoma can be effectively treated with CAR-T cell therapy

Recurrent mantle cell lymphoma can be effectively treated with CAR-T cell therapy

A one-year follow-up led by the University of Texas MD Anderson Cancer Center found that most patients with mantle cell lymphoma (mantle cell lymphoma) who are resistant to previous treatments can benefit from chimerism that targets CD19 antigen...

2020-09-30
Elucidating the mechanism of T cell depletion is expected to improve cancer immunotherapy

Elucidating the mechanism of T cell depletion is expected to improve cancer immunotherapy

In the latest research report published in the international journal “Immunity”, scientists at Emory University have studied the “depleted” immune cells caused by chronic viral infections to provide information on how to improve cancer immunotherapy ...

2020-09-30
How to use CRISPR gene editing technology to improve human white blood cells and effectively fight cancer?

How to use CRISPR gene editing technology to improve human white blood cells and effectively fight cancer?

A few days ago, in the United States, researchers used gene editing tools to treat three patients with advanced cancer for the first time. At the same time, the results of the phase 1 clinical trial showed high expectations...

2020-09-30
Use convertible CAR-T cells to attack potential HIV

Use convertible CAR-T cells to attack potential HIV

Researchers from the Gladstone Institute of Virology and Immunology and other scientific institutes have used transformable CAR-T cells to attack potential HIV and established indications...

2020-09-30
Mesenchymal stem cell transplantation is expected to treat gastric ulcers caused by non-steroidal anti-inflammatory drugs

Mesenchymal stem cell transplantation is expected to treat gastric ulcers caused by non-steroidal anti-inflammatory drugs

In high-income countries, non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most important causes of peptic ulcer disease...

2020-09-30