【Animal Modeling】-Types of β-amyloid and the Pathogenesis Model of Alzheimer

Inoculation of mice with brain homogenates from sporadic Alzheimer\\\'s disease patients elicited cerebral amyloid deposition in recipients, suggesting that the amyloid beta (Aβ) peptide may self-proliferate as a prion...

2022-09-30

【Animal modeling】-Effect of rosuvastatin on myocardial matrix metalloproteins and inflammatory factors in rats with acute myocardial infarction

To observe the changes of matrix metalloproteinase MMPs, TIMP2 and inflammatory factors TNF-α and IL-1β in myocardial tissue of rats with acute myocardial infarction (AMI) treated with rosuvastatin...

2022-09-30

【Animal Modeling】-Why do rodents in arid areas have high drug resistance?

Recently, the innovation team of grassland pest and rodent monitoring and prevention and control of the Institute of Plant Protection, Chinese Academy of Agricultural Sciences, by comparing the molecular evolution characteristics of drug resistance-r...

2022-09-30

【Animal Modeling】-Expression of NF-κB in Hepatocytes of Rats with Welfare Injury Induced by Braking

To study the expression changes of NF-κB in hepatocytes of rats with welfare injury induced by immobilization...

2022-09-30

【Animal Modeling】-CBA/CaJ Mice Organ Weight, Blood Physiological and Biochemical Indexes and Immune Cell Proportion

To determine the basic biological indicators of SPF CBA/CaJ mice, and to lay a foundation for better use of this strain of mice for biomedical research...

2022-09-30

【Animal Modeling】-Comparison of two different reagents for the four detection results of hemagglutination in SD rats

To compare the four-item (PT, APTT, TT, FIB) detection results of hemagglutination reagents from two different manufacturers, imported and domestic, on experimental animals SD rats and humans, and to observe whether there is any difference between th...

2022-09-30

【Animal Modeling】-Study on changes in the number and traits of cardiac fibroblasts in early postnatal mice

Cardiac fibroblasts account for more than 50% of cardiac cells and play an important role in cardiac physiology and pathology...

2022-09-30

【Animal Modeling】-Determination of blood concentration of carbamazepine in rats after administration and its NMR metabolomics analysis

To analyze the effect of carbamazepine on the serum metabolome of rats after intragastric administration using nuclear magnetic resonance (NMR)-based metabolomics technology...

2022-09-30

【Animal modeling】-Protective effect of atorvastatin on joint injury in ApoE-/- mice

To observe the protective effect of atorvastatin on joint injury in ApoE-/- mice...

2022-09-30

[Animal modeling] - Effect of electroacupuncture on synaptic plasticity and microglial cell polarization in rats with cerebral ischemia

To investigate the effects of electroacupuncture on synaptic plasticity and microglial polarization in rats with focal cerebral ischemia, and to detect the expression of miR-21/signal transducer and activator of transcription 3 (STAT3) pathway...

2022-09-29

[Animal modeling] - Inhibitory effect of cytomegalovirus on some immune indexes of mice implanted with polymethylmethacrylate

To study the inhibitory effect of cytomegalovirus (CMV) on immune response of mice implanted with polymethyl methacrylate (PMMA)...

2022-09-29

[Animal modeling] - Protective effect of curcumin on acute renal injury in rats with pregnancy induced hypertension

To investigate the protective effect of curcumin on acute renal injury induced by pregnancy induced hypertension in rats and explore its potential mechanism...

2022-09-29

[Animal modeling] - Experimental study on lung tissue damage in rats caused by dental grinding dust

To evaluate the effects of cobalt chromium molybdenum metal (trade name: Vitaline), zirconia porcelain and polymethyl methacrylate resin on lung injury in rats...

2022-09-29

[Animal modeling] - Effect of prostacyclin E1 on hepatic fibrosis in rabbits after hepatic artery iodized oil embolization

To investigate the effect of prostacyclin E1 on the expression of Smad2 and Smad4 mRNA in rabbits with hepatic fibrosis after hepatic artery iodized oil embolization...

2022-09-29

[Animal modeling] Protective effect of atorvastatin on joint injury in ApoE -/- mice

To observe the protective effect of atorvastatin on joint injury in ApoE -/- mice...

2022-09-29

[Animal modeling] - Effect of Oct4 and Cdx2 on differentiation of bovine embryo inner cell mass and trophoblast

To study the effect of Oct4 and Cdx2 knockdown on the gene expression related to the differentiation of bovine ICM and TE, and to explain the role of Oct4 and Cdx2 in the early development of bovine embryos...

2022-09-29