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【Animal modeling】- Breeding and genotype identification of Bmal1 clock gene knockout mice

【Animal modeling】- Breeding and genotype identification of Bmal1 clock gene knockout mice

To breed and identify the genotype of Bmal1 knockout mice to provide an ideal animal model for biological rhythm research...

2022-05-07
【Animal modeling】-Effect of p53 knockout on neurobehavior and the number of neurons in barrel cortex in mice

【Animal modeling】-Effect of p53 knockout on neurobehavior and the number of neurons in barrel cortex in mice

To explore the role of p53 gene in neurobehavioral activity in mice and its effect on the number of neurons in barrel cortex...

2022-05-07
【Animal modeling】-Establishment and preliminary application of FO-PCR detection method for mouse pox virus

【Animal modeling】-Establishment and preliminary application of FO-PCR detection method for mouse pox virus

To establish a TaqMan probe-based fluorescent quantitative PCR detection method for mouse pox virus (ECTV), and to detect the nude mole rat tissue samples, mouse tissue samples and chinchilla tissue samples preserved in the laboratory...

2022-05-07
【Animal Modeling】-Relationship between vascular calcification and bone metabolism markers in rats with chronic kidney disease

【Animal Modeling】-Relationship between vascular calcification and bone metabolism markers in rats with chronic kidney disease

To study the correlation between vascular calcification and serum bone metabolism markers in chronic kidney disease (CKD) rats...

2022-05-07
【Animal Modeling】-Relationship between the expression of vitamin D metabolizing enzyme CYP24A1 in testis of adult tree shrew and fertility

【Animal Modeling】-Relationship between the expression of vitamin D metabolizing enzyme CYP24A1 in testis of adult tree shrew and fertility

To study the transcript levels of vitamin D metabolizing enzymes and vitamin D receptors in the testis of adult tree shrew, detect the protein expression of CYP24A1, and explore the causes of reproductive disorders in male experimental tree shrew...

2022-05-07
【Animal Modeling】-Analysis and establishment and hematopoietic phenotype of Marcksl1 knockout mice

【Animal Modeling】-Analysis and establishment and hematopoietic phenotype of Marcksl1 knockout mice

To establish Marcksl1 knockout mice, and to preliminarily explore the effect of this gene deletion on the development of hematopoietic system...

2022-05-07
【Animal modeling】-Prnp-SNCA-A53T Parkinson\'s disease transgenic mice with different intestinal flora

【Animal modeling】-Prnp-SNCA-A53T Parkinson's disease transgenic mice with different intestinal flora

A number of evidences indicate that the intestinal flora of Parkinson\'s disease patients is abnormal, and whether Prnp-SNCA-A53T Parkinson\'s disease transgenic mice also have intestinal flora dysbiosis has not been reported. Microbial ecological ch...

2022-05-07
【Animal modeling】-Isolation and identification of exosomes from skin fibroblasts of naked mole rats

【Animal modeling】-Isolation and identification of exosomes from skin fibroblasts of naked mole rats

To isolate and culture naked mole rat skin fibroblasts, identify them, and explore whether naked mole rat skin fibroblasts have the ability to secrete exosomes...

2022-05-06
【Animal Modeling】-Effect and mechanism of fine particulate matter PM2.5 on atherosclerosis in ApoE knockout mice

【Animal Modeling】-Effect and mechanism of fine particulate matter PM2.5 on atherosclerosis in ApoE knockout mice

The purpose of this experiment was to investigate the effect and mechanism of fine particulate matter PM2.5 on ApoE knockout (Apoe-/-) mice (atherosclerosis model mice)...

2022-05-06
【Animal Modeling】-Screening of polymorphic microsatellite loci of guinea pig individuals and strains

【Animal Modeling】-Screening of polymorphic microsatellite loci of guinea pig individuals and strains

To screen polymorphic microsatellite markers in guinea pigs and provide basic information for identifying the genetic structure and gene location of guinea pigs...

2022-05-06
【Animal Modeling】-miR-122 Expression Changes and Action Mechanisms in Kidney Tissues of Mice with Diabetic Nephropathy

【Animal Modeling】-miR-122 Expression Changes and Action Mechanisms in Kidney Tissues of Mice with Diabetic Nephropathy

To investigate the expression changes of miR-122 in the kidney tissue of diabetic nephropathy mice and the effect and possible mechanism of silencing miR-122 on the kidney tissue of DN mice...

2022-05-06
【Animal Modeling】-Changes in the structure and function of the immune system of SD rats during natural aging

【Animal Modeling】-Changes in the structure and function of the immune system of SD rats during natural aging

To observe the changes in the structure and function of the immune system in naturally aged SD rats, and to explore the possible mechanisms?...

2022-05-06
【Animal modeling】-neural function and histomorphological changes of the jejunum of early type 1 diabetic rats

【Animal modeling】-neural function and histomorphological changes of the jejunum of early type 1 diabetic rats

To investigate the function of nitrergic and cholinergic nerves in jejunal smooth muscle and the morphological changes of jejunum in early stage type 1 diabetic rats...

2022-05-06
【Animal Modeling】-Optimization of PCR detection method for Pasteurella pneumophila in mice and its preliminary application in different sample processing

【Animal Modeling】-Optimization of PCR detection method for Pasteurella pneumophila in mice and its preliminary application in different sample processing

To establish a real-time, rapid, sensitive and simple PCR method for the detection of Pasteurella pneumophila in living experimental animals...

2022-05-06
【Animal Modeling】-Small ubiquitin-like modifier protease 3 regulates autophagy in mouse alveolar type II epithelial cells

【Animal Modeling】-Small ubiquitin-like modifier protease 3 regulates autophagy in mouse alveolar type II epithelial cells

To investigate the regulatory effect and molecular mechanism of small ubiquitin-like modifier-specific protease 3 on autophagy in mouse lung tissue...

2022-05-06
【Animal modeling】-Validation of the effect of SPF golden hamster cage and drinking water pulsed vacuum sterilization

【Animal modeling】-Validation of the effect of SPF golden hamster cage and drinking water pulsed vacuum sterilization

To confirm the performance of the pulse vacuum sterilizer, and to verify the effect of pulse vacuum sterilization on the SPF golden hamster cage and drinking water under the specified loading method and sterilization conditions...

2022-05-06