【Animal Modeling】-The role of cAMP/CREB/BDNF signaling pathway in vortioxetine against depression-like behavior in mice

To study the effect of vortioxetine, a novel antidepressant, on cyclic adenosine monophosphate/cyclic adenosine monophosphate response element binding protein/brain-derived neurotrophic factor signal transduction pathway...

2022-07-20

【Animal modeling】-Hydroxyethyl starch 40 sodium chloride injection allergic experimental study

To evaluate the allergic safety of hydroxyethyl starch 40 sodium chloride injection...

2022-07-20

【Animal Modeling】-Lactobacillus rhamnosus culture supernatant prevents Escherichia coli meningitis by inhibiting NF-κB pathway

To investigate whether Lactobacillus rhamnosus supernatant (LGG-CM) can block bacterial meningitis caused by E. coli K1 strain by inhibiting NF-κB pathway in vitro...

2022-07-20

【Animal modeling】-Observe the effect of fibroblast growth factor-2/polylactic acid-polyethylene glycol-polylactic acid/bone morphogenetic protein-2 (FGF-2/PELA/BMP-2) microcapsule scaffold on SD rats

To observe the effect of fibroblast growth factor-2/polylactic acid-polyethylene glycol-polylactic acid/bone morphogenetic protein-2 (FGF-2/PELA/BMP-2) microcapsule scaffold on the formation of periosteum-derived stem cells in SD rats. Bone different...

2022-07-20

【Animal modeling】-FGF-2/PELA/BMP-2 microcapsule scaffold promotes the osteogenic differentiation of rat periosteum-derived stem cells

To observe the effect of fibroblast growth factor-2/polylactic acid-polyethylene glycol-polylactic acid/bone morphogenetic protein-2 (FGF-2/PELA/BMP-2) microcapsule scaffold on the formation of periosteum-derived stem cells in SD rats. Bone different...

2022-07-20

【Animal Modeling】-Polyethylene oxide improves blood perfusion of chronic ischemic hindlimb in rats

To evaluate the effect of polyethylene oxide (PEO) on improving blood perfusion of chronic ischemic hindlimb in rats by contrast echocardiography...

2022-07-20

【Animal modeling】-The improvement effect of treadmill exercise on the motor function of elderly rats

To investigate the change rule of rat motor function with increasing age, and the improvement effect of exercise on the motor function of elderly rats...

2022-07-20

【Animal modeling】-Combined with high-resolution MRI and micro-CT to evaluate the repairing effect of Taohong Siwu Decoction on femoral head necrosis in rabbits

To establish a rabbit model of steroid-induced necrosis of the femoral head, and to evaluate the repairing effect of Taohong Siwu Decoction on the microscopic bony structure damage of SIONFH combined with high-resolution MRI and micro-CT...

2022-07-20

【Animal modeling】-Proliferation of oligodendrocyte precursor cells in vitro by conditioned medium of rat Schwann cell line RSC96

To observe the effect of rat Schwann cell line RSC96 cell conditioned medium (RSC96-CM) on the proliferation of oligodendrocyte precursor cells (OPCs), and to explore its mechanism...

2022-07-19

【Animal Modeling】-Ultrasonic radiation force combined with targeted ultrasound microbubbles to evaluate renal ischemia-reperfusion injury in mice

To investigate the sensitivity and feasibility of ultrasonic radiation force to promote the adhesion of targeted microbubbles to improve the detection of renal ischemia-reperfusion injury...

2022-07-19

【Animal modeling】-Protective effect of nimodipine on H2O2-induced apoptosis of PC12 cells

To investigate the protective effect of nimodipine on the apoptosis of PC12 cells induced by hydrogen peroxide (H2O2)...

2022-07-19

【Animal modeling】-Study on the synergistic and detoxification effect of pine pollen on cyclophosphamide

To study whether pine pollen has synergistic and attenuating effects on cyclophosphamide chemotherapy...

2022-07-19

【Animal Modeling】-Mechanism of platelets in salt-sensitive hypertension through inflammatory response

To investigate the role and molecular mechanism of platelets in high-salt-induced salt-sensitive hypertension...

2022-07-19

【Animal modeling】-Protective effect of Guanxinning tablet on myocardial ischemia-reperfusion injury in rats

To observe the effect of Guanxinning Tablets (GXNT) on myocardial infarction and cardiac autonomic function in rats with myocardial ischemia-reperfusion injury (MI/RI)...

2022-07-19

【Animal modeling】-Effect of Fkbp51 knockout on alternative splicing of mouse liver transcriptome

To study the effect of Fkbp51 knockout on gene alternative splicing in liver tissue by analyzing the expression profiles of Fkbp51 gene knockout and wild-type mice livers...

2022-07-19

【Animal Modeling】-Effect of intrauterine injection of absolute ethanol on estrous cycle in mice

To investigate the effect of intrauterine injection of absolute ethanol on the estrous cycle of mice...

2022-07-19