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【Animal modeling】-Effect of hypoxia on the expressions of drug transporters MDR1 and MRP2 in rats

【Animal modeling】-Effect of hypoxia on the expressions of drug transporters MDR1 and MRP2 in rats

To study the effects of simulated rapid altitude hypoxia on some physiological indexes and the expressions of MDR1 and MRP2 efflux drug transporters in the small intestine, liver and kidney of rats, and to preliminarily explore the effect of high alt...

2022-07-20
【Animal Modeling】-Effects of chronic arsenic exposure on brain and serum metabolomics in mice

【Animal Modeling】-Effects of chronic arsenic exposure on brain and serum metabolomics in mice

To observe the effects of chronic arsenic exposure on the metabolomics of mouse cortex and serum, and to explore its neurotoxicity mechanism...

2022-07-20
【Animal Modeling】-The relationship between sex differences in blood pressure and sodium channels in mouse kidneys

【Animal Modeling】-The relationship between sex differences in blood pressure and sodium channels in mouse kidneys

To study blood pressure, renal urinary sodium excretion and related renal sodium channels and signaling pathways in male and female mice, and to preliminarily explore the relationship between sex differences in blood pressure and renal sodium channel...

2022-07-20
【Animal modeling】-Protective effect of liraglutide on stress-stressed chronic heart failure in rats

【Animal modeling】-Protective effect of liraglutide on stress-stressed chronic heart failure in rats

To study the effect and mechanism of liraglutide on cardiac function in pressure-stressed chronic heart failure rats...

2022-07-20
【Animal Modeling】-Study on vascular calcification and expression of vascular wall osteopontin and osteocalcin in aged rats

【Animal Modeling】-Study on vascular calcification and expression of vascular wall osteopontin and osteocalcin in aged rats

To study the occurrence of vascular calcification in aged rats, and the changes of osteopontin and osteocalcin expression in the arterial vessel wall of aged rats...

2022-07-20
【Animal Modeling】-Drug efficacy and pain mechanism in mice with adenomyosis

【Animal Modeling】-Drug efficacy and pain mechanism in mice with adenomyosis

To understand the efficacy and pain mechanism of drug therapy in mice with adenomyosis...

2022-07-20
【Animal Modeling】-Discussion on the pathological evaluation method of polio vaccine intracerebral monkey neurovirulence test

【Animal Modeling】-Discussion on the pathological evaluation method of polio vaccine intracerebral monkey neurovirulence test

To investigate the pathological evaluation method of polio vaccine in monkey neurovirulence test by intracerebral method...

2022-07-20
【Animal modeling】-Comparative study of bone metabolism in WHBE rabbits with forelimb deformity based on OPG/RANK/RANKL system

【Animal modeling】-Comparative study of bone metabolism in WHBE rabbits with forelimb deformity based on OPG/RANK/RANKL system

To use the OPG/RANK/RANKL system to compare and study the bone metabolism characteristics of WHBE rabbits with forelimb deformity...

2022-07-20
【Animal modeling】-The effect of glutamine combined with umbilical cord blood mesenchymal stem cell transplantation on intestinal ischemia-reperfusion injury in rats

【Animal modeling】-The effect of glutamine combined with umbilical cord blood mesenchymal stem cell transplantation on intestinal ischemia-reperfusion injury in rats

To investigate the effect of glutamine combined with cord blood mesenchymal stem cells (MSCs) transplantation on intestinal ischemia-reperfusion injury in rats...

2022-07-20
【Animal modeling】-Effect of low selenium diet on the expressions of CD163, CD206 and CCR7 in the liver and kidney of rats

【Animal modeling】-Effect of low selenium diet on the expressions of CD163, CD206 and CCR7 in the liver and kidney of rats

To investigate the effect of low selenium diet on liver and kidney in rats, and the role of macrophage polarization to M1 and M2 in liver and kidney fibrosis...

2022-07-20
【Animal Modeling】-Glucagon-like polypeptide-1 improves learning and memory ability in type 2 diabetic rats

【Animal Modeling】-Glucagon-like polypeptide-1 improves learning and memory ability in type 2 diabetic rats

To observe the improvement effect of diabetes treatment drug glucagon-like peptide-1 (GLP-1) on learning and memory dysfunction in diabetic rats...

2022-07-20
【Animal Modeling】-Tumor necrosis factor-α-induced protein-8-like molecule 2 promotes apoptosis of CD4-positive T cells in heat-injured mice

【Animal Modeling】-Tumor necrosis factor-α-induced protein-8-like molecule 2 promotes apoptosis of CD4-positive T cells in heat-injured mice

To investigate the effect of tumor necrosis factor-α-induced protein-8-like molecule 2 (TIPE2) on apoptosis of spleen CD4+ T lymphocytes in a mouse model of severe scald...

2022-07-20
【Animal modeling】-The regulatory effect of Quqi powder on telomerase activity in precancerous lesions of liver cancer

【Animal modeling】-The regulatory effect of Quqi powder on telomerase activity in precancerous lesions of liver cancer

To investigate the role of telomerase in the formation and development of precancerous lesions of hepatocellular carcinoma and the regulation mechanism of the prescription mistletoe powder (HQS) and the monarch drug mistletoe on its activity...

2022-07-20
【Animal Modeling】-Depression-like behavioral changes in male and female rats induced by restraint stress of different durations

【Animal Modeling】-Depression-like behavioral changes in male and female rats induced by restraint stress of different durations

To investigate the effects of chronic restraint stress of different restraint durations on the depression-like behavior of male and female SD rats, and to provide a basis for the selection of experimental animals\' gender and experimental duration in...

2022-07-20
【Animal modeling】-Changes of IL-6, SOD and MDA in the lung tissue of rats with acute pulmonary edema

【Animal modeling】-Changes of IL-6, SOD and MDA in the lung tissue of rats with acute pulmonary edema

To investigate the changes and significance of malondialdehyde, superoxide dismutase and interleukin-6 in lung tissue of acute hypoxia-induced acute pulmonary edema in rats...

2022-07-20
【Animal modeling】-The protective effect and mechanism of miRNA-29c in rat cerebral ischemia-reperfusion nerve injury

【Animal modeling】-The protective effect and mechanism of miRNA-29c in rat cerebral ischemia-reperfusion nerve injury

To investigate the protective effect and mechanism of miRNA-29c in rat cerebral ischemia-reperfusion nerve injury...

2022-07-20