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【Animal modeling】-Comparative study on steroid hormone synthesis ability of mice with drug-induced deficiency syndrome induced by cisplatin continuous and interval modeling

【Animal modeling】-Comparative study on steroid hormone synthesis ability of mice with drug-induced deficiency syndrome induced by cisplatin continuous and interval modeling

To study the effect of different dosage regimens of cisplatin on steroid hormone synthesis and reserve function in mice...

2022-06-17
【Animal Modeling】-miR-122 Expression Changes and Action Mechanisms in Kidney Tissues of Mice with Diabetic Nephropathy

【Animal Modeling】-miR-122 Expression Changes and Action Mechanisms in Kidney Tissues of Mice with Diabetic Nephropathy

To investigate the expression changes of miR-122 in the kidney tissue of diabetic nephropathy mice and the effect and possible mechanism of silencing miR-122 on the kidney tissue of DN mice...

2022-06-17
【Animal Modeling】-Effect of long-term high-protein diet on hepatic steatosis and fat accumulation in OVX mice

【Animal Modeling】-Effect of long-term high-protein diet on hepatic steatosis and fat accumulation in OVX mice

To investigate the effect of long-term high-protein diet on liver and adipose tissue in ovariectomized mice and the effect of glucagon-like peptide-1...

2022-06-17
【Animal Modeling】-Effect and mechanism of androgens on gastric mucosal mitochondrial function in aged rats

【Animal Modeling】-Effect and mechanism of androgens on gastric mucosal mitochondrial function in aged rats

To investigate the effect and mechanism of androgens on gastric mucosal mitochondrial function in aged rats with orchiectomy (GDX)...

2022-06-17
【Animal Modeling】-Protective Mechanism of Bamboo Phytophthoracin A on Liver Ischemia-Reperfusion in Rats

【Animal Modeling】-Protective Mechanism of Bamboo Phytophthoracin A on Liver Ischemia-Reperfusion in Rats

To investigate the protective mechanism of phyllostachysin A on hepatic ischemia-reperfusion injury in rats...

2022-06-17
【Animal modeling】-Effect of Jiangxiangru water extract on gastrointestinal physiology, biochemistry and immune function in hyperlipidemia rats

【Animal modeling】-Effect of Jiangxiangru water extract on gastrointestinal physiology, biochemistry and immune function in hyperlipidemia rats

To investigate the therapeutic improvement effect of Jiangxiangru water extract on hyperlipidemia model rats, and to provide modern pharmacological basis for the traditional efficacy of Jiangxiangru for warming the stomach, invigorating the spleen an...

2022-06-17
【Animal modeling】-Effect of astragaloside Ⅱ on IL-21/STAT3 pathway and airway inflammation in juvenile asthmatic rats

【Animal modeling】-Effect of astragaloside Ⅱ on IL-21/STAT3 pathway and airway inflammation in juvenile asthmatic rats

To investigate the effect of astragaloside Ⅱ on the interleukin-21 ( IL-21 ) / signal transducer and activator of transcription 3 ( STAT3 ) pathway and airway inflammation in juvenile asthmatic rats...

2022-06-17
【Animal modeling】-Effect of microcystin-LR on mitochondrial function of mouse primary hepatocytes

【Animal modeling】-Effect of microcystin-LR on mitochondrial function of mouse primary hepatocytes

Microcystin contamination caused by cyanobacterial blooms is one of the worldwide concerns. Microcystin LR (MC-LR) has strong specific hepatotoxicity, but its exact mechanism of liver injury has not been fully elucidated. To solve this problem, this ...

2022-06-17
【Animal Modeling】-The effect of carbon tetrachloride-induced acute liver injury on the heart in a rat model

【Animal Modeling】-The effect of carbon tetrachloride-induced acute liver injury on the heart in a rat model

To investigate the effect of carbon tetrachloride (CCl4) on cardiac function and morphology in rats with acute liver injury...

2022-06-17
【Animal Modeling】-Study on the alleviation of exercise via FoxO1-lipophagy pathway. Study on hyperlipidemia in ApoE-/- mice

【Animal Modeling】-Study on the alleviation of exercise via FoxO1-lipophagy pathway. Study on hyperlipidemia in ApoE-/- mice

Lipophagy is a selective autophagy targeting adipose and is regulated by FoxO1. As an effective means of regulating lipid metabolism disorders, there is no report on whether exercise is related to FoxO1-lipophagy process in hyperlipidemia. In this st...

2022-06-17
【Animal Modeling】-Effect of REST/NRSF on depression and anxiety-like behavior in corticosterone stress model mice

【Animal Modeling】-Effect of REST/NRSF on depression and anxiety-like behavior in corticosterone stress model mice

To study the expression of REST in corticosterone model mice and the effect of REST expression on depression and anxiety behavior in mice, and to explore its role in the mouse model of depression...

2022-06-17
【Animal Modeling】-Intervention of Fufang Dihuang Granules on Microglia Activation and Neurobehavior in Parkinson\'s Disease Model Rats

【Animal Modeling】-Intervention of Fufang Dihuang Granules on Microglia Activation and Neurobehavior in Parkinson's Disease Model Rats

To investigate the intervention effect of Fufang Dihuang Granules on the activation of nigrostriatal microglia, the expression of inflammatory factors and neurobehavior in different rat models...

2022-06-17
【Animal Modeling】-Antibiotic-induced microbiome depletion promotes intestinal colonization of Campylobacter jejuni in mice

【Animal Modeling】-Antibiotic-induced microbiome depletion promotes intestinal colonization of Campylobacter jejuni in mice

To establish a method for intestinal colonization of C57BL/6 mice by Campylobacter jejuni through antibiotic-induced gut microbiome depletion...

2022-06-17
【Animal modeling】-Evaluation of the curative effect of Shenling Baizhu powder on ulcerative colitis model mice

【Animal modeling】-Evaluation of the curative effect of Shenling Baizhu powder on ulcerative colitis model mice

To explore the curative effect of Shenling Baizhu powder on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) model mice...

2022-06-17
【Animal modeling】-The improvement effect of Baixiangdan capsule on premenstrual anxiety disorder caused by ovariectomy in rats

【Animal modeling】-The improvement effect of Baixiangdan capsule on premenstrual anxiety disorder caused by ovariectomy in rats

To compare traditional Chinese medicine Baixiangdan Capsules (BXD), serotonin 3 receptor (5-HT3R) specific agonists and their antagonists, cannabinoid receptor 1 (CB1R) specific agonists and their antagonists through a series of behavioral tests. Int...

2022-06-16
【Animal modeling】-Effect and safety of domestic porcine small intestinal submucosa acellular matrix for dura mater repair in rabbits

【Animal modeling】-Effect and safety of domestic porcine small intestinal submucosa acellular matrix for dura mater repair in rabbits

To construct a dural defect model in New Zealand white rabbits, and to evaluate the effectiveness of the biodegradable patch in repairing dural defect by observing the physiological state, clinical manifestations and histopathological changes of the ...

2022-06-16