【Animal Modeling】-FoxO3A Gene Knockout Mice Breeding Identification and Primary Analysis of Bone Marrow Hematopoietic Stem Cell Phenotype

To breed and identify FOXO3A knockout mice. The selected FOXO3A knockout heterozygous mice were used for breeding, and the homozygous mice were used for experiments...

2022-06-21

【Animal Modeling】-Expression of Perilipin in Kidney Tissue of Rats with Diabetic Nephropathy

To observe the characteristics of rat diabetic nephropathy model and the diagnostic value of urinary LN for early DN, and to explore the expression of perilipin (Plin) in the kidneys of DN rats...

2022-06-21

【Animal Modeling】-Establishment and application of real-time PCR detection method for mouse cytomegalovirus

To establish a fluorescent quantitative PCR method for mouse cytomegalovirus and make a preliminary application...

2022-06-21

【Animal modeling】-Effect of alprostadil on eIF2α/ATF4/CHOP pathway and liver function in fulminant liver failure rats

To investigate the effect of alprostadil (PGE1) on liver function in rats with fulminant liver failure (FHF), and to investigate its effect on eukaryotic translation initiation factor 2α (eIF2α) / activating transcription factor 4 (ATF4) / C/ EBP Reg...

2022-06-20

【Animal modeling】-Effect of salidroside on Nrf2/Keap1 signaling pathway and wound healing in diabetic foot ulcer rats

To investigate the effect of salidroside (Sal) on nuclear transcription factor E2-related factor 2 / Kelch-like epichlorohydrin-related protein 1 (Nrf2 / Keap1) signaling pathway and wound healing in diabetic foot ulcer (DFU) rats...

2022-06-20

【Animal Modeling】-Regulatory effects of corstine on skin inflammation and autophagy in psoriasis mice by inhibiting C5a/C5aR1 pathway

To investigate the regulatory effect of Cosentyx on skin inflammation and autophagy in psoriatic mice through the C5a/C5aR1 pathway through the imiquimod (IMQ) mouse model of psoriasis...

2022-06-20

【Animal Modeling】-Effect of Qingre Runzao Oral Liquid on the upstream and downstream cytokines of ILC2s in asthmatic mice

To intervene ovalbumin (OVA)-sensitized asthmatic mice with Qingre Runzao Oral Liquid, and to observe its effect on the number of type II innate lymphocytes (ILC2s) and its upstream and downstream cytokines in asthmatic mice...

2022-06-20

【Animal Modeling】-Research on the analgesic effects of Lugai Qishan Fluoxane on labor and delivery based on MAPK signaling hypoxia

To investigate the effect of sevoflurane labor analgesia on hypoxia in neonatal rats based on the mitogen-activated protein kinase (MAPK) signaling pathway...

2022-06-20

【Animal Modeling】-Safflower Yellow Pigment Protects the Kidneys of Mice with Diabetic Nephropathy and Its Mechanism

To investigate the renal protective effect and mechanism of safflower yellow on streptozotocin-induced diabetic nephropathy in mice...

2022-06-20

【Animal Modeling】-Discuss the pharmacodynamic effect and preliminary mechanism of action of oxymatrine, the active ingredient in Sophora flavescens, in the treatment of atopic dermatitis mice

To observe the chronic toxicity of Deinococcus radiodurans R1 to SD rats...

2022-06-17

【Animal modeling】-Protective effect of oxymatrine on atopic dermatitis model mice

To investigate the efficacy and preliminary mechanism of oxymatrine, the active ingredient in Sophora flavescens, in the treatment of atopic dermatitis mice...

2022-06-17

【Animal modeling】-Relevant mechanism of hypertonic saline protecting blood-brain barrier and reducing cerebral edema in rats with cerebral hemorrhage

To investigate the related mechanism of hypertonic saline treatment in reducing cerebral edema in rats with cerebral hemorrhage...

2022-06-17

【Animal Modeling】-Effect of Yanlishuangkouhan Dropping Pills on immune cell subsets and NF-κB signaling pathway in rabbits with chronic pharyngitis

To explore the effect and mechanism of Yanlishuangkouhan dropping pills on chronic pharyngitis rabbit model...

2022-06-17

【Animal modeling】-Dynamic changes of tumor-infiltrating immune cells in MC38 colon cancer mice

To observe the dynamic changes of tumor-infiltrating immune cells during tumor development in tumor-bearing mice...

2022-06-17

【Animal modeling】-Intervention effect of chitosan on PM2.5-induced acute lung injury in mice

To investigate the intervention effect of chitosan on PM2.5-induced acute lung injury in mice...

2022-06-17

【Animal Modeling】-The brain protection effect and mechanism of regular aerobic exercise on cerebral ischemia rats

To study the protective mechanism of regular aerobic exercise on brain tissue in rats with cerebral ischemia...

2022-06-17