【Animal modeling】-The effect of paeoniflorin on Bayk8644-induced depression-anxiety-like behavior in rats and its mechanism

To investigate the pharmacological mechanism of paeoniflorin in improving depression-anxiety-like behavior in rats based on L-type voltage-dependent calcium channel...

2022-06-22

【Animal modeling】-Effect of Tongxinluo capsule on inflammatory response, brain edema and cognitive function in rats exposed to hypobaric hypoxia

To investigate the neuroprotective effect of Tongxinluo capsule on cognitive impairment in rats exposed to acute hypobaric hypoxia and its related mechanism...

2022-06-22

【Animal Modeling】-Knockout of Leptin Receptor Causes Activation of Microglia in Rat Brain Tissue

To analyze the morphological and functional changes of microglia in the brain of leptin receptor (LEPR) knockout rats, and to explore the function of leptin receptor in microglia. effect....

2022-06-22

【Animal Modeling】-Preliminary study on the effect of lipopolysaccharide on the lung tissue of naked mole rats

To observe and analyze the effects of lipopolysaccharide on the morphological structure and pathological indexes of the lungs of naked mole-rats, and to preliminarily explore whether the naked mole-rats have LPS tolerance...

2022-06-22

【Animal modeling】-Effect of Helicobacter hepatica infection on dextran sulfate sodium-induced chronic colitis model in mice

To investigate the effect of Helicobacter hepatica infection on chronic colitis induced by sodium dextran sulfate in mice...

2022-06-22

【Animal Modeling】-Exploring the effect of stress on appetite in rats from the brain-stomach ghrelin pathway

To study the molecular mechanism of stress affecting appetite from the brain ghrelin pathway...

2022-06-22

【Animal Model】-Effect of α-mangostin on the immune function of immunosuppressed mice

To investigate the effect of α-mangostin on the immune function of cyclophosphamide-induced immunosuppression in mice, and to provide experimental basis for the follow-up mechanism research and the development of new drugs to increase immune function...

2022-06-22

【Animal modeling】-Protective effect of curcumin on acute kidney injury in pregnant hypertensive rats

To investigate the protective effect of curcumin on acute kidney injury induced by gestational hypertension in rats and explore its potential mechanism...

2022-06-22

【Animal Modeling】-Experimental Study on Lung Tissue Injury Induced by Dental Grinding Dust in Rats

To evaluate the effects of three kinds of dental grinding dusts of cobalt-chromium-molybdenum metal (trade name: Vitaline), zirconium dioxide porcelain and polymethyl methacrylate resin on lung tissue injury in rats...

2022-06-22

【Animal modeling】-Effect of Naoshuantong capsule on the expression of inflammatory factors in aorta of ApoE-/- mice

To observe the effect of Naoshuantong capsule on the expression of inflammatory related factors interleukin-1β, interleukin-6, tumor necrosis factor, intercellular adhesion molecule-1 and metalloproteinase-9 in ApoE-/- atherosclerosis mouse model. Th...

2022-06-22

【Animal Modeling】-VEGF-A Inhibitor sFLT-1 Improves Renal Function in Type 1 Diabetic Mice

To investigate whether the VEGF-A inhibitor sFLT-1 can reverse the renal damage in type 1 diabetic mice by inhibiting the activation and inflammatory response of vascular endothelial cells...

2022-06-22

【Animal Modeling】-Hydrogen peroxide-induced changes in isolated rat uterine ligament fibroblasts

To investigate the effect and possible mechanism of oxidative stress on the proliferation, apoptosis, collagen synthesis and inflammatory factor expression of uterine ligament fibroblasts...

2022-06-22

【Animal Modeling】-Effect of two-color coreopsis alcohol extract on intestinal flora of type 2 diabetic mice

To explore the possible link between the alcoholic extract of coreopsis bicolor, intestinal flora and type 2 diabetes mellitus...

2022-06-21

【Animal modeling】-Effect of curcumin on glucose transport and PI3K/Akt signaling pathway in adipocytes of type 2 diabetic rats

To investigate the effect of curcumin on glucose transport and phosphatidylinositol kinase-3 (PI3K)/protein kinase B (Akt) signaling pathway in adipocytes of type 2 diabetes mellitus (T2DM) rats...

2022-06-21

【Animal modeling】-Polymorphism analysis of PPARγ2 gene promoter in Wuzhishan miniature pigs

To analyze the polymorphisms in the regulatory region of the PPARγ2 gene promoter in Wuzhishan miniature pigs...

2022-06-21

【Animal Modeling】-Changes and Significance of Arterial Blood Gas Analysis in Rats with Chronic Hypoxic Pulmonary Hypertension

To investigate the changes and significance of arterial blood gas analysis indexes in a rat model of hypoxic pulmonary hypertension induced by chronic hypoxia...

2022-06-21