【Animal modeling】-Pathological changes of amyloidosis and cerebrovascular disease in Alzheimer

To investigate the pathological changes of brain tissue of amyloidosis cerebrovascular lesions on the basis of establishing an experimental rat model of Alzheimer\\\'s disease...

2022-06-13

【Animal modeling】-Effect of simvastatin PLGA sustained-release microspheres on intervertebral disc degeneration in rats

To investigate the efficacy of local injection of simvastatin PLGA sustained-release microspheres in the treatment of intervertebral disc degeneration in rats...

2022-06-09

【Animal modeling】-Negative pressure sealing drainage combined with heparin lavage in the treatment of rabbit scald and seawater immersion wounds

To observe the effect of negative pressure sealing drainage combined with heparin solution lavage on the healing of rabbit back scald combined with seawater immersion...

2022-06-09

【Animal modeling】-Expression and immunolocalization of the main egg antigen Sjp40 of Schistosoma japonicum in the liver of New Zealand white rabbits

To observe the expression of Sjp40 in infected New Zealand white rabbits with hepatic sediment eggs and the formation of granuloma lesions, and to perform immunolocalization...

2022-06-09

【Animal modeling】-Effect of acute incision pain on the expression of connexin Cx43 in the dorsal horn of spinal cord in rats

To observe the effect of acute incision pain on the expression of connexin43 (Cx43) in the dorsal horn of rat spinal cord...

2022-06-09

【Animal Modeling】- Establishment of Swimming Endurance Experimental System in Mice and Verification of Anti-fatigue Effect of Rhodiola rosea

To establish a mouse swimming endurance experimental system, explore new indicators for evaluating the swimming endurance of mice, and use this system to verify the effect of Rhodiola rosea on the endurance of mice...

2022-06-08

【Animal modeling】-Bama pig NK cell phenotype identification and establishment of pig CIK cell induction method

To obtain the data of the phenotype and proportion of NK cells in the peripheral blood lymphocytes of Bama pigs, and to establish a high-efficiency method for inducing and culturing porcine CIK cells in vitro...

2022-06-08

【Animal Modeling】-TALEN Construction of Fndc5 Gene Knockout Mice and Preliminary Analysis

To provide an animal model for subsequent research by constructing Fndc5 knockout mice...

2022-06-08

【Animal modeling】-Analysis of hepatitis B virus related indexes in urine of HBV transgenic mice

To detect and analyze the expression of HBV-related indicators in the urine of HBV transgenic mice, and to further understand the biological characteristics of transgenic mice; and to determine the tissue source of HBV-related indicators in urine thr...

2022-06-08

【Animal Modeling】-Analysis of the weight of main organs and blood physiological and biochemical indexes in mice with congenital cataract

Establishment of background data on body weight, main organ weight, blood physiology and biochemistry of SPF-grade congenital cataract mice...

2022-06-08

【Animal Modeling】-Preliminary study on the structural and functional differences of reproductive system between fertile and infertile male naked mole rats

To observe and analyze the differences in reproductive system structure and function between fertile and infertile male naked mole-rats, and preliminarily explore the reasons why male infertile individuals cannot reproduce...

2022-06-08

【Animal modeling】-Analysis of microsatellite DNA genetic diversity in specific pathogen-free Jinding duck

To analyze the genetic diversity of specific pathogen-free Jinding duck population using microsatellite markers...

2022-06-08

【Animal modeling】-Construction and expression of human IL-37b gene eukaryotic expression vector

To construct pEGFP-N1/IL-37b eukaryotic expression vector, and to detect its expression in THP-1 cells...

2022-06-08

【Animal modeling】-In vitro co-culture of bovine blastocysts induces differential expression of integrin αv, β3 genes in endometrial epithelial cells

　　Objective: Using the co-culture method of bovine embryos and endometrial epithelial cells in vitro, to explore the changes of integrin αv, β3 gene differential expression in endometrial epithelial cells before and after co-culture, in order to esta...

2022-06-08

【Animal Modeling】-Constructing severe combined immunodeficiency mice based on CRISPR/Cas9 technology

To use CRISPR/Cas9 technology to target knockout of Rag2 gene encoding mouse T and B cells and IL2rg gene encoding NK cells, and to construct T, B cells and NK cells combined immunodeficiency mice...

2022-06-08

【Animal modeling】-GGTA1-/- Wuzhishan miniature pig SLA class I gene molecular characteristics and similarity analysis with HLA

To clarify the molecular structure of SLA class I gene of Wuzhishan miniature pig with α-1,3 galactosyltransferase gene knockout (GGTA1-/-) and its similarity with human HLA, and to study the cellularity of xenotransplantation. Rejection is important...

2022-06-08