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【Animal Modeling】-Transcranial ultrasound perfusion imaging performance and safety evaluation in rats after skull thinning

【Animal Modeling】-Transcranial ultrasound perfusion imaging performance and safety evaluation in rats after skull thinning

To observe and quantitatively evaluate the performance of right brain transcranial ultrasound perfusion imaging by thinning the local skull of SD rats to improve the acoustic window, and to preliminarily evaluate the effect of bone grinding and trans...

2022-03-10
【Animal Modeling】-A comparative study of in situ liver cancer dynamic imaging and pathology in nude mice

【Animal Modeling】-A comparative study of in situ liver cancer dynamic imaging and pathology in nude mice

To dynamically monitor tumor growth in nude mice after orthotopic liver cancer modeling and to compare it with pathology, so as to determine the appropriate period of intervention therapy...

2022-03-10
【Animal modeling】-Characteristics of liver pathological damage in db/db mice with spontaneous type 2 diabetes

【Animal modeling】-Characteristics of liver pathological damage in db/db mice with spontaneous type 2 diabetes

To dynamically observe the pathological changes and characteristics of the liver of db/db mice with spontaneous type 2 diabetes mellitus, and to provide the basic theory and experimental basis for the experimental study of using the liver of db/db mi...

2022-03-10
【Animal Modeling】-Analysis of fecal microbial diversity of wild tree shrews using Illumina MiSeq sequencing platform

【Animal Modeling】-Analysis of fecal microbial diversity of wild tree shrews using Illumina MiSeq sequencing platform

To analyze the structure and composition of the fecal flora of wild tree shrew by high-throughput sequencing technology, and to lay a foundation for the further development and utilization of this new experimental animal...

2022-03-10
【Animal modeling】-Detection and analysis of multiple cytokines in serum of rhesus monkeys and cynomolgus monkeys

【Animal modeling】-Detection and analysis of multiple cytokines in serum of rhesus monkeys and cynomolgus monkeys

To determine and compare basal serum cytokine levels in healthy rhesus monkeys and cynomolgus monkeys...

2022-03-10
Reproducibility study of microsatellite marker detection method for genetic quality control of laboratory animals

Reproducibility study of microsatellite marker detection method for genetic quality control of laboratory animals

To verify whether the microsatellite marker detection method in the group standard is applied to the genetic quality detection of experimental animals, and whether it has good repeatability in three laboratories...

2022-03-10
【Animal Modeling】-Isolation and Culture of Primary Tree Shrews Corneal Stromal Cells

【Animal Modeling】-Isolation and Culture of Primary Tree Shrews Corneal Stromal Cells

To explore a simple and easy method for rapid isolation and culture of tree shrew corneal stromal cells in vitro...

2022-03-09
【Animal modeling】-CRISPR/Cas9 system-mediated reproduction and identification of Slc6a6 knockout rats

【Animal modeling】-CRISPR/Cas9 system-mediated reproduction and identification of Slc6a6 knockout rats

To construct a taurine transporter knockout rat by CRISPR/Cas9 technology, breed and identify it, and provide a stable rat model for studying the effect of taurine deficiency on nervous system diseases...

2022-03-09
【Animal Modeling】-Based on the luciferase dual reporter gene system to verify in vitro that the Cip4 gene of gerbils is regulated by RXR and T4

【Animal Modeling】-Based on the luciferase dual reporter gene system to verify in vitro that the Cip4 gene of gerbils is regulated by RXR and T4

To investigate the regulatory effects of nuclear transcription factors TRB, RXR and agonist T4 on Cip4 gene expression in gerbils...

2022-03-09
【Animal Modeling】-Application of Heat Pipe Air Heat Exchanger in the Construction of Laboratory Animal Facilities

【Animal Modeling】-Application of Heat Pipe Air Heat Exchanger in the Construction of Laboratory Animal Facilities

To use the heat pipe air heat exchanger to exchange heat with the gas discharged from the laboratory animal facility, recover the temperature energy in the exhaust gas, and use the recovered energy in the fresh air to reduce the energy consumption of...

2022-03-08
【Animal modeling】-D-galactose increases the expression of IL-18 in the gut of tree shrew and the intestinal flora imbalance

【Animal modeling】-D-galactose increases the expression of IL-18 in the gut of tree shrew and the intestinal flora imbalance

To analyze the expression of IL-18 in the intestinal tissue of tree shrew and the changes of intestinal flora under the action of D-galactose...

2022-03-08
【Animal modeling】-Analysis of peripheral blood and immune cell typing of aged and young SD rats

【Animal modeling】-Analysis of peripheral blood and immune cell typing of aged and young SD rats

To compare the differences of peripheral blood and immune cell typing indexes between aged SD rats and young SD rats...

2022-03-08
【Animal modeling】-The killing effect of PBLC of guinea pigs with different FMDV susceptibility on simulated FMDV-infected cells

【Animal modeling】-The killing effect of PBLC of guinea pigs with different FMDV susceptibility on simulated FMDV-infected cells

To investigate the genetic and immunological mechanisms of guinea pigs resistance to foot-and-mouth disease virus (FMDV). To elucidate the feasibility of FMDV pseudovirus-infected cells for studying FMDV pathogenesis...

2022-03-08
【Animal modeling】-Comparative study on the microbial composition of different parts of the digestive tract of wild tree shrew and artificially reared tree shrew

【Animal modeling】-Comparative study on the microbial composition of different parts of the digestive tract of wild tree shrew and artificially reared tree shrew

Using tree shrew as a research model to explore the composition of microbiota in different intestinal segments of wild tree shrew and artificially bred tree shrew...

2022-03-08
【Animal modeling】-Screening CA16 pathogenic related genes using genetically diverse mouse resources

【Animal modeling】-Screening CA16 pathogenic related genes using genetically diverse mouse resources

Coxsackievirus A16 is one of the main pathogenic pathogens of hand, foot and mouth disease, and its pathogenic mechanism is not yet clear....

2022-03-08
【Animal modeling】-Establishment and validation of electroporation transfection conditions for mouse macrophage RAW264.7 cells

【Animal modeling】-Establishment and validation of electroporation transfection conditions for mouse macrophage RAW264.7 cells

To screen and verify the conditions of electroporation for transfection of TRIB3 overexpression plasmid and TRIB3 siRNA in RAW264.7 cells, and to establish the optimal electroporation transfection scheme for RAW264.7 cells...

2022-03-08