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【Animal modeling】-α-synuclein A53T mutation impairs cognitive function in mice

【Animal modeling】-α-synuclein A53T mutation impairs cognitive function in mice

To explore the changes of cognitive function, motor function, anxiety-like behavior and pathological changes in α-synuclein A53T transgenic mice...

2022-03-08
【Animal modeling】-Isolation, identification and drug sensitivity test of Proteus mirabilis from cynomolgus monkeys

【Animal modeling】-Isolation, identification and drug sensitivity test of Proteus mirabilis from cynomolgus monkeys

To provide theoretical and technical support for microbial detection of imported experimental monkeys and how to carry out feeding management and disease prevention and control by identifying and drug susceptibility testing of Proteus mirabilis isola...

2022-03-08
【Animal Modeling】-Construction of Bpi Gene Knockout Mice Using CRISPR/Cas9 Technology

【Animal Modeling】-Construction of Bpi Gene Knockout Mice Using CRISPR/Cas9 Technology

To use CRISPR/Cas9 gene editing technology to efficiently construct Bpi gene knockout mouse model, and to continue to breed, identify and build stable genetic Bpi gene knockout mouse strains...

2022-03-08
【Animal modeling】-Establishment of standard biological indicators of SD rats in GLP barrier environment animal laboratory

【Animal modeling】-Establishment of standard biological indicators of SD rats in GLP barrier environment animal laboratory

To establish the biological indicators of normal SD rats in the long-term toxicity test in the barrier environment animal laboratory of the Chinese Medicine Safety Evaluation Center (CLP), and to provide reference indicators for future researchers...

2022-03-08
【Animal Modeling】- Histopathological study of skin healing in miniature pigs after deep second-degree burns

【Animal Modeling】- Histopathological study of skin healing in miniature pigs after deep second-degree burns

To establish a pig model of deep second-degree scald, and to observe the histopathological changes of skin repaired at different time points...

2022-03-08
【Animal Modeling】- Transcriptome Analysis of Human Cells Infected by Porcine Circovirus Type 2

【Animal Modeling】- Transcriptome Analysis of Human Cells Infected by Porcine Circovirus Type 2

Whether circovirus 2 can infect human cells has been a topic of debate...

2022-03-08
【Animal Modeling】-Study on the correlation between SLC1A2 gene SNP locus and the activity of Labrador retrievers and golden retrievers

【Animal Modeling】-Study on the correlation between SLC1A2 gene SNP locus and the activity of Labrador retrievers and golden retrievers

To detect the correlation between the SNP locus of SLCIA2 gene and the activity of Labrador retrievers and golden retrievers, in order to screen effective genetic molecular markers for the early selection and breeding of guide dogs...

2022-03-07
【Animal modeling】-Behavioral differences in learning and memory ability of C57BL/6J, BALB/c, ICR strain mice

【Animal modeling】-Behavioral differences in learning and memory ability of C57BL/6J, BALB/c, ICR strain mice

To compare the behavioral differences of learning and memory ability of C57BL/6J, BALB/c and ICR strain mice...

2022-03-07
【Animal Modeling】-Optimization of Mouse Embryo Transfer Technology and Purification of Cytomegalovirus

【Animal Modeling】-Optimization of Mouse Embryo Transfer Technology and Purification of Cytomegalovirus

To establish a purification method for cytomegalovirus in mice to obtain mice without MCMV infection...

2022-03-07
【Animal Modeling】-Expression profile of TRIM26 in major tissues and organs of human and mouse

【Animal Modeling】-Expression profile of TRIM26 in major tissues and organs of human and mouse

To clarify the expression location and level of TRIM26 in different tissues and organs of human and mouse...

2022-03-07
【Animal modeling】-Gene cloning and preliminary functional study of junctional adhesion molecule A in tree ferrets

【Animal modeling】-Gene cloning and preliminary functional study of junctional adhesion molecule A in tree ferrets

To obtain the full-length coding sequence of junctional adhesion molecule A in tree ferrets and analyze its molecular characteristics, and to explore the mechanism of JAM-A as a receptor for reovirus invading primary lung cells of tree ferrets...

2022-03-07
【Animal Modeling】-Changes of Sex Hormone Levels in Plasma and Tissue of Female Green Fluorescent Nude Mice at Different Periods

【Animal Modeling】-Changes of Sex Hormone Levels in Plasma and Tissue of Female Green Fluorescent Nude Mice at Different Periods

To understand the changes of estrogen, progesterone, prolactin in plasma and prolactin and prolactin receptor mRNA levels in male green fluorescent nude mice in different pregnancy and lactation periods...

2022-03-07
【Animal modeling】-The relationship between serum TF, TM, vWF levels and CRT formation in SD rats

【Animal modeling】-The relationship between serum TF, TM, vWF levels and CRT formation in SD rats

To establish a rat model of external jugular vein catheter-related thrombosis (CRT), to observe the formation of CRT in rats, and to detect serum tissue factor (TF), thrombomodulin (TM) and von Willebrand disease in rats. Factor (vWF) content, to stu...

2022-03-07
【Animal modeling】-IVC cage changing standard operating procedures and the risk of transmission of mouse virus pathogens

【Animal modeling】-IVC cage changing standard operating procedures and the risk of transmission of mouse virus pathogens

To study the risk of virus infection in mice raised with IVC equipment in the standard operating procedure of cage changing in independent ventilation cages and laboratory animal negative pressure barrier facilities...

2022-03-07
【Animal modeling】-Gene cloning and preliminary functional study of junctional adhesion molecule A in tree ferrets

【Animal modeling】-Gene cloning and preliminary functional study of junctional adhesion molecule A in tree ferrets

To obtain the full-length coding sequence of junctional adhesion molecule A in tree ferrets and analyze its molecular characteristics, and to explore the mechanism of JAM-A as a receptor for reovirus invading primary lung cells of tree ferrets...

2022-03-07
【Animal modeling】-Establishment and preliminary application of FO-PCR detection method for mouse pox virus

【Animal modeling】-Establishment and preliminary application of FO-PCR detection method for mouse pox virus

To establish a TaqMan probe-based fluorescent quantitative PCR detection method for mouse pox virus (ECTV), and to detect the nude mole rat tissue samples, mouse tissue samples and chinchilla tissue samples preserved in the laboratory...

2022-03-07