【Animal Modeling】-Experimental Study on Changes of Platelet Mitochondria after Tourniquet Limb Ischemia-Reperfusion Injury in Rats

To investigate the changes of platelet mitochondria after tourniquet ischemia-reperfusion injury, and to provide guidance for the clinical application of tourniquet...

2022-03-01

【Animal modeling】-RNA interference specifically blocks the effect of local angiotensin II type 1 receptor on the first-phase insulin secretion in pancreatic islets

To observe the changes of insulin secretion in the first phase of pancreatic islets in db/db mice after blocking the expression of local angiotensin II type 1 receptor (AT1R) by RNA interference technology, and to explore its potential mechanism...

2022-03-01

【Animal modeling】-Protective effect of piperphentonamine hydrochloride on gentamicin-induced hearing loss in guinea pigs

To observe the relationship between guinea pig cochlear autophagy-related proteins beclin1 and LC3, Na+-K+-2Cl- co-transporter (NKCC1) mRNA, endothelin (ET) expression and cochlear gentamicin (GM) injury and piperphentonamine hydrochloride (PPTA) pro...

2022-03-01

【Animal modeling】-Protective effect of Apelin-13 on focal cerebral ischemia-reperfusion injury in rats

To investigate the protective effect of Apelin-13 on focal cerebral ischemia-reperfusion injury (CIRI) in rats and its possible mechanism...

2022-03-01

【Animal modeling】-Effect of thalidomide on bisphosphonate-related osteonecrosis of the jaw

To study the effect of thalidomide on bisphosphonate-related osteonecrosis of the jaw...

2022-03-01

【Animal Modeling】-Effects of hesperidin on antioxidant activity and gene expression of antioxidant enzymes in mice

To investigate the effect of hesperidin on the antioxidant effect of the body...

2022-03-01

【Animal Modeling】-Metabolic rate determines primate brain development and lifespan

Researchers at Loyola University Chicago, co-authors of the groundbreaking study, found that humans have a higher metabolic rate than closely related primates, allowing humans to evolve to be larger brain...

2022-03-01

【Animal Modeling】-Aniline-induced DNA damage in mouse hepatocytes and lymphocytes and its repair effect

To study the genotoxicity of aniline and its repair kinetics...

2022-03-01

【Animal modeling】-Effect of octachlorodibenzodioxin on gene expression profile of mouse testis tissue

To investigate the effect of octachlorodibenzodioxins on the changes of gene expression profiles in the testis of male mice...

2022-03-01

【Animal modeling】-The protective effect of Zhenwu decoction on the heart of mice with uremic cardiomyopathy induced by most nephrectomy

To investigate the cardioprotective effect and mechanism of Zhenwu Decoction on uremic cardiomyopathy in mice...

2022-03-01

【Animal Modeling】-Effects of Four Commonly Used Experimental Anesthetics on Cardiovascular System of Rats

To investigate the effects of different animal experimental anesthetics on the cardiovascular system of rats...

2022-03-01

【Animal modeling】-Losartan reduces ventilator-related lung injury in mice and inhibits the expression of caveolin-1 and NOX4 in lung tissue

To establish a mouse model of mechanical lung injury by ventilator hyperventilation, intervene with angiotensin II receptor inhibitor losartan, and explore the effect of losartan on caveolin-1 in the lung of mice with mechanically ventilated lung inj...

2022-03-01

【Animal modeling】-nicotine inhibits MIA-induced apoptosis of rat osteoarthritis chondrocytes

To investigate the inhibition of nicotine on the apoptosis of osteoarthritis chondrocytes induced by sodium iodoacetate (MIA)...

2022-02-28

【Animal modeling】-Construction and effect evaluation of Noggin gene silencing expression vector

To construct lentivirus-mediated Noggin RNAi interference sequences, and to analyze the silencing effect of these interference sequences on Noggin gene...

2022-02-28

【Animal Modeling】-Effect of triptolide on the expression of Notch pathway receptors and ligand genes in rats with adjuvant arthritis pulmonary function

To observe the effect of triptolide (TPT) on the expression of Notch receptor and ligand in adjuvant arthritis (AA) rats...

2022-02-28

【Animal modeling】-Estrogen reduces microvascular injury induced by chronic hypoperfusion in rat brain by up-regulating VEGF expression

By detecting the pathological changes of cerebral microvessels in different periods after permanent ligation of bilateral common carotid arteries (BCCAO) in rats and the effect of physiological dose of 17-β-estradiol (E2) replacement therapy, to expl...

2022-02-28