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【Animal Modeling】-Repair of bone defects around implants in small pigs

【Animal Modeling】-Repair of bone defects around implants in small pigs

Implant restoration has been more and more widely used clinically, but it is usually related to the excessive absorption of alveolar bone after tooth loss due to trauma, tumor, periodontal disease and other reasons, which leads to more bone mass and...

2023-01-16
[Animal modeling]-Safety evaluation, migration and distribution of hBMSCs transplanted into the brain of juvenile cynomolgus monkeys

[Animal modeling]-Safety evaluation, migration and distribution of hBMSCs transplanted into the brain of juvenile cynomolgus monkeys

To evaluate the safety of hBMSCs transplanted into the brain of juvenile cynomolgus monkeys, and to further observe the migration and distribution of hBMSCs in the brain, so as to establish a new technical platform and theoretical basis for the treat...

2023-01-16
Y chromosome loss or a risk factor for Alzheimer\\\\

Y chromosome loss or a risk factor for Alzheimer

Because male blood cells do not have a Y chromosome, they are more likely to be diagnosed with Alzheimer\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\'s disease. In addition, it is a factor that increases the risk of death, including many types of cancer...

2023-01-16
【Animal Modeling】-Mice model of lung metastasis and postoperative recurrence after bone marrow injection

【Animal Modeling】-Mice model of lung metastasis and postoperative recurrence after bone marrow injection

Establish a model of bone marrow injection for the treatment of lung metastasis and postoperative recurrence, clarify the superiority and feasibility of the model established by bone marrow injection, and provide a new research basis for the study of...

2023-01-16
[Animal Modeling]-VEGF-A inhibitor sFLT-1 improves renal function in type 1 diabetic mice

[Animal Modeling]-VEGF-A inhibitor sFLT-1 improves renal function in type 1 diabetic mice

To investigate whether the VEGF-A inhibitor sFLT-1 can inhibit the activation and inflammation of vascular endothelial cells, thereby reversing the renal damage in type 1 diabetic mice...

2023-01-16
【Animal Modeling】-Establishment and Evaluation of Chronic Gastritis Model in Mice Infected by Helicobacter Pylori

【Animal Modeling】-Establishment and Evaluation of Chronic Gastritis Model in Mice Infected by Helicobacter Pylori

Establish an animal model of Helicobacter pylori infection to evaluate the pathological changes of the gastric mucosa of Helicobacter pylori-related chronic gastritis...

2023-01-16
【Animal modeling】-Effect of Astragalus on endoplasmic reticulum stress response in vascular remodeling in hypertensive rats

【Animal modeling】-Effect of Astragalus on endoplasmic reticulum stress response in vascular remodeling in hypertensive rats

To study the effect of Astragalus on endoplasmic reticulum stress response (ERS) in vascular remodeling in hypertensive rats, and to explore the molecular mechanism of its vascular protection...

2023-01-16
[Disease animal model]-Animal cardiomyopathy model caused by intraperitoneal injection of adriamycin

[Disease animal model]-Animal cardiomyopathy model caused by intraperitoneal injection of adriamycin

Doxorubicin 2.5 mg/kg body weight was injected intraperitoneally into Wistar rats weighing 170 to 200 g at two-week intervals three times a week, and then administered for another week...

2023-01-16
【Animal Modeling】-Expression and significance of basic leucine zipper transcription factor ATF-like protein in kidney tissue of lupus mice

【Animal Modeling】-Expression and significance of basic leucine zipper transcription factor ATF-like protein in kidney tissue of lupus mice

To explore the expression and clinical significance of basic leucine zipper transcription factor ATF-like protein (ATF-like, BATF) in the kidney tissue of lupus mice...

2023-01-16
[Animal Modeling]-Simultaneous measurement of the brain activities of two monkeys shows that \\\\\\\"synchronization of thoughts\\\\\\\" or the key to primate neural mechanisms

[Animal Modeling]-Simultaneous measurement of the brain activities of two monkeys shows that "synchronization of thoughts" or the key to primate neural mechanisms

American scientists measured the brain activity of two monkeys at the same time for the first time, and found that social interaction may lead to synchronization of monkey brain activity...

2023-01-14
【Animal modeling】-The role of stromal cell-derived factor-1 and chemokine receptor 4 in the rejection of rat corneal transplantation

【Animal modeling】-The role of stromal cell-derived factor-1 and chemokine receptor 4 in the rejection of rat corneal transplantation

To investigate the expressions of stromal cell-derived factor-1 (SDF-1) and stromal cell-derived factor-1 (CXCR4) in rat corneal tissue and their roles in immune rejection after keratoplasty...

2023-01-14
【Animal modeling】-Effect of Bushen Cuovv Decoction on ovarian morphology and sex hormones in polycystic ovary syndrome model rats

【Animal modeling】-Effect of Bushen Cuovv Decoction on ovarian morphology and sex hormones in polycystic ovary syndrome model rats

To explore the mechanism of Bushen Cuovv Decoction in the treatment of polycystic ovary syndrome by observing the effects of Bushen Cuovv Decoction on sex hormones, anti-Müllerian hormone and ovarian morphology in polycystic ovary syndrome model rats...

2023-01-14
【Animal Modeling】-Advances in animal experiments on radiation heart injury

【Animal Modeling】-Advances in animal experiments on radiation heart injury

During radiotherapy of chest and abdomen tumors, the heart located in the mediastinum is inevitably exposed to heart damage caused by radiation, collectively referred to as radiation-induced heart damage (RIHD).This disease has been considered as imp...

2023-01-14
【Animal modeling】-Construction and research of eukaryotic expression vector of full-length and mature IL-37b

【Animal modeling】-Construction and research of eukaryotic expression vector of full-length and mature IL-37b

To construct the eukaryotic expression vector pEGFP N1/IL-37b of full-length and mature IL-37b, and to detect the expression of both in RAW 264.7 cells...

2023-01-14
【Animal Modeling】-Comparison of Different Methods of Inducing THP-1 Cell Differentiation

【Animal Modeling】-Comparison of Different Methods of Inducing THP-1 Cell Differentiation

To optimize different methods to stimulate the directional differentiation of THP-1 cells into M1, M2 macrophages and DC cells, and lay the foundation for the study of three in vitro cell models of M1, M2 and DC...

2023-01-14
【Animal modeling】-Effect of knockout TRPC6 on MPTP-induced neuroinflammatory injury in mice

【Animal modeling】-Effect of knockout TRPC6 on MPTP-induced neuroinflammatory injury in mice

To detect the expression of TRPC6 channel in microglia in a mouse MPTP-induced neuroinflammation model, and to explore the effect of TRPC6 channel on inflammatory expression and dopaminergic neuron damage...

2023-01-13