【Animal Modeling】-Establishment and Application of In Vitro Culture System of Mouse Small Intestinal Organoids

To establish an in vitro model of intestinal epithelial cells—small intestinal organoid culture system, and to explore its related pathological detection techniques, so as to provide a convenient platform for the in vitro research of intestinal-relat...

2022-10-26

【Animal Modeling】-Effect of bis(2-ethyl)hexyl phthalate exposure during pregnancy on the growth and development of mouse placenta

To observe the effects of DEHP exposure on placental growth and development, the number of uNK cells at the maternal-fetal interface and angiogenesis in mice by exposure to di(2-ethyl)hexyl phthalate (DEHP) during pregnancy...

2022-10-26

【Animal modeling】-Effect of prostacyclin E1 on hepatic fibrosis in rabbits after hepatic arterial lipiodol embolization

To investigate the effect of prostacyclin E1 on the mRNA expression levels of Smad2 and Smad4 in rabbits with hepatic fibrosis after hepatic arterial lipiodol embolization...

2022-10-26

【Animal modeling】-phenotype and pathological observation of leptin receptor gene knockout SD rats

To observe various parameters of the leptin receptor gene knockout rat model of obesity, metabolic syndrome and prediabetes established by CRISPR/Cas9 technology, and to provide a more ideal basis for the molecular mechanism research of metabolic dis...

2022-10-26

【Animal modeling】-Mechanism of transient receptor potential channel C1 in airway remodeling in guinea pig asthma and the intervention effect of budesonide

To explore the mechanism of TRPC1 ion channel in the evolution of airway remodeling and the intervention effect of budesonide by interfering with the expression of transient receptor potential channel C1 (TRPC1)...

2022-10-26

【Animal modeling】-Effect of postconditioning with dezocine on acute lung injury induced by intestinal ischemia-reperfusion in rats

To investigate the effect and possible mechanism of dezocine postconditioning on acute lung injury induced by intestinal ischemia-reperfusion in rats...

2022-10-26

How to construct animal models of type II diabetes in rats and mice?

How to construct animal models of type II diabetes in rats and mice? This question has been asked by many netizens, so today Zhonghong Boyuan will give you a technical sharing....

2022-10-26

[Animal Modeling]-Mouse stem cells can form "embryonic" structures in vitro

A team of European scientists published a medical paper in the British journal Nature, claiming that they only used mouse stem cells to cultivate structures similar to early embryos in petri dishes....

2022-10-26

【Animal Modeling】-Depression-like behavioral changes in male and female rats induced by restraint stress of different durations

To investigate the effects of chronic restraint stress of different restraint durations on the depression-like behavior of male and female SD rats, and to provide a basis for the selection of experimental animals\\\' gender and experimental duration ...

2022-10-26

【Animal Modeling】- Establishment of Swimming Endurance Experimental System in Mice and Verification of Anti-fatigue Effect of Rhodiola rosea

To establish a mouse swimming endurance experimental system, explore new indicators for evaluating the swimming endurance of mice, and use this system to verify the effect of Rhodiola rosea on the endurance of mice...

2022-10-26

[Animal modeling] - Construction and evaluation of two models of obese polycystic ovary syndrome with insulin resistance in rats

To establish an animal model of obese polycystic ovary syndrome (PCOS) with insulin resistance by two different ways combined with high-fat diet, and compare its endocrine and metabolic characteristics...

2022-10-26

[Animal modeling] - Establishment of a mouse model of abdominal aortic aneurysm and analysis of its histological characteristics

To establish an abdominal aortic aneurysm model in C57BL/6J mice by perfusion of porcine trypsin and evaluate its pathological changes...

2022-10-26

【Animal modeling】-Effect of dexmedetomidine on renal function and tight junction protein expression in septic rats

To investigate the effect of dexmedetomidine on renal function and tight junction protein expression in septic rats...

2022-10-26

【Animal modeling】-The expression and ultrastructural observation of kidney-yang deficiency-related mRNA in the hypothalamus of Lewis rats

To further study the kidney-yang deficiency constitution of Lewis rats by observing the gene expression and ultrastructure related to kidney-yang deficiency in the hypothalamus of Lewis rats...

2022-10-26

【Animal modeling】-C57-ras transgenic mouse model hybrid growth and development characteristics of the first generation of CB6F1

To determine the growth and development characteristics of the self-established transgenic carcinogenicity model C57-ras mice and BALB/c mice for one generation, and to provide basic data for the commercial supply of this model...

2022-10-26

【Animal modeling】-Comparative study on bone growth in rats after long-term exposure to low-fluoride aluminum and short-term high-fluoride aluminum exposure

To observe the effects of different doses of fluoride and aluminum combined with the duration of intake on longitudinal bone growth and bone metabolism in rats...

2022-10-26