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【Animal Modeling】-Skin cells come from genetically modified pigs

【Animal Modeling】-Skin cells come from genetically modified pigs

Recently, the US Food and Drug Administration (FDA) approved XenoTherapeutics to initiate the first clinical trial of xenotransplantation...

2022-10-26
【Disease animal model】-induced atopic dermatitis animal model

【Disease animal model】-induced atopic dermatitis animal model

The small molecule hapten combines with proteins in the body to form a complete antigen, which is absorbed by Langerhans cells. The corresponding antigen is presented to T cells and activated, and contact dermatitis occurs again...

2022-10-24
【Animal Modeling】-Experimental study of cabozantinib in blocking Listeria monocytogenes infection in mice

【Animal Modeling】-Experimental study of cabozantinib in blocking Listeria monocytogenes infection in mice

To investigate the possibility of cabozantinib, a c-Met receptor tyrosine kinase inhibitor, as a novel drug against Listeria monocytogenes infection...

2022-10-24
【Animal Modeling】-Study on changes in the number and traits of cardiac fibroblasts in early postnatal mice

【Animal Modeling】-Study on changes in the number and traits of cardiac fibroblasts in early postnatal mice

Cardiac fibroblasts account for more than 50% of cardiac cells and play an important role in cardiac physiology and pathology. The 7th day after birth is a turning point when the heart loses its ability to regenerate. This study aimed to study the ch...

2022-10-24
【Animal modeling】- PERV-env gene cloning and tissue expression profiling in Guangxi Bama miniature pigs

【Animal modeling】- PERV-env gene cloning and tissue expression profiling in Guangxi Bama miniature pigs

To clone part of PERV-env gene of Guangxi Bama miniature pig, and study its expression difference in different tissues...

2022-10-24
【Animal modeling】-Protective effect of atorvastatin on joint injury in ApoE-/- mice

【Animal modeling】-Protective effect of atorvastatin on joint injury in ApoE-/- mice

To observe the protective effect of atorvastatin on joint injury in ApoE-/- mice...

2022-10-24
【Animal Modeling】-Icariin on the Androgen Receptor Signaling Pathway in SCID Mice Prostate Cancer Orthotopic Transplantation Tumor

【Animal Modeling】-Icariin on the Androgen Receptor Signaling Pathway in SCID Mice Prostate Cancer Orthotopic Transplantation Tumor

How to observe the effect of icariin on the androgen receptor signaling pathway in prostate cancer orthotopic xenografts in SCID mice?...

2022-10-24
[Animal Modeling]-Brain immune memory affects neurological disease progression in mice

[Animal Modeling]-Brain immune memory affects neurological disease progression in mice

The immune response in mice affects the severity of late-stage brain diseases in mice through immune memory...

2022-10-24
【Animal Modeling】-The influence of multiple knee joint defects

【Animal Modeling】-The influence of multiple knee joint defects

Since articular cartilage does not heal naturally, there is no cure for methods that can regenerate hyaline cartilage in a consistent and predictable manner. Some recognized cartilage repair methods include minimally invasive (MFX) and matrix-induced...

2022-10-24
【Animal modeling】-Effects of epithelial sodium channels on osteoclast differentiation and bone resorption in rats

【Animal modeling】-Effects of epithelial sodium channels on osteoclast differentiation and bone resorption in rats

This article investigates the effect of epithelial sodium channel (ENaC) on the function and activity of osteoclasts...

2022-10-22
【Animal Modeling】-Effect of endometriosis on the fertility of mice

【Animal Modeling】-Effect of endometriosis on the fertility of mice

To establish a mouse model of endometriosis, and to observe the effect of endometriosis on the pregnancy ability of the model mice...

2022-10-22
【Animal modeling】-Nude mouse prostate cancer metastasis model

【Animal modeling】-Nude mouse prostate cancer metastasis model

Even after transplantation due to immunodeficiency, nude mice that have undergone human tumor xenotransplantation also grow well. The morphological and functional characteristics of human tumors transplanted into nude mice are basically the same as t...

2022-10-22
【Animal Modeling】-Establishment and preliminary application of multiplex PCR method for Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae

【Animal Modeling】-Establishment and preliminary application of multiplex PCR method for Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae

To establish a multiplex PCR detection method for Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae, and to provide a rapid, sensitive and simple method for bacterial detection in experimental animals...

2022-10-22
【Animal modeling】-Comparison of calcium chelated collagen polypeptide and estrogen on bone improvement in ovariectomized rats

【Animal modeling】-Comparison of calcium chelated collagen polypeptide and estrogen on bone improvement in ovariectomized rats

To compare the bone-improving effect of calcium chelated collagen polypeptide (CPCC) with that of estrogen, and to lay a foundation for the research and development of safe osteoporosis prevention and treatment drugs...

2022-10-22
【Animal modeling】-Effect of short needling method on the expression of Sox9, VEGF and ColⅩ in rabbit knee osteoarthritis chondrocytes

【Animal modeling】-Effect of short needling method on the expression of Sox9, VEGF and ColⅩ in rabbit knee osteoarthritis chondrocytes

To observe the effect of short needling method on the expression of sex-determining region (Sox9), vascular endothelial cell growth factor (VEGF) and type X collagen (ColⅩ) in articular chondrocytes of rabbit knee osteoarthritis (KOA) articular carti...

2022-10-22
【Animal Modeling】-Other congenital heart disease models in miniature pigs

【Animal Modeling】-Other congenital heart disease models in miniature pigs

Guerreiro et al. established a model of growing pig myocardial hypertrophy using surgical methods. The experiment used 4-month-old pigs to establish aortic-pulmonary shunt through surgery, and then reared to 7 months of age. 4 weeks after surgery, pu...

2022-10-22