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【Animal modeling】-Effect of modified Wuzhuyu decoction on hypertension and vascular endothelial function in rats induced by high sugar, high fat and alcohol consumption

【Animal modeling】-Effect of modified Wuzhuyu decoction on hypertension and vascular endothelial function in rats induced by high sugar, high fat and alcohol consumption

To investigate the effect of modified Wuzhuyu Decoction on blood pressure and vascular endothelial function in hypertensive model rats induced by high-sugar and high-fat diet and drinking...

2022-06-23
【Animal Modeling】-Therapeutic effect of anti-C5aR antibody combined with allicin on induced inflammatory bowel disease in rats

【Animal Modeling】-Therapeutic effect of anti-C5aR antibody combined with allicin on induced inflammatory bowel disease in rats

To explore the therapeutic effect of anti-complement 5a receptor (C5aR) antibody combined with allicin on inflammatory bowel disease (IBD) in rats...

2022-06-23
【Animal modeling】- Down-regulation of miR-128-3p alleviates inflammatory response and lung histomorphology in acute lung injury in septic rats

【Animal modeling】- Down-regulation of miR-128-3p alleviates inflammatory response and lung histomorphology in acute lung injury in septic rats

To investigate the effect of down-regulation of miR-128-3p on inflammatory response and lung histomorphology in acute lung injury in septic rats...

2022-06-23
【Animal modeling】-Sex differences in peripheral blood and immune cell phenotypes in SD rats in the aging process

【Animal modeling】-Sex differences in peripheral blood and immune cell phenotypes in SD rats in the aging process

To compare and analyze the gender differences of immune cell typing indexes in peripheral blood and immune organs of SD rats of different months of age...

2022-06-23
【Animal Modeling】-Evaluation of the effect of midazolam and butorphanol on anesthesia in mice before isoflurane anesthesia

【Animal Modeling】-Evaluation of the effect of midazolam and butorphanol on anesthesia in mice before isoflurane anesthesia

To observe the anesthesia effect and internal environment stability of mice receiving midazolam combined with butorphanol before isoflurane anesthesia, and evaluate the safety...

2022-06-23
【Animal modeling】-The effect of liraglutide on the expression and mechanism of key enzymes PEPCK and G6pase in hepatic gluconeogenesis in diabetic mice

【Animal modeling】-The effect of liraglutide on the expression and mechanism of key enzymes PEPCK and G6pase in hepatic gluconeogenesis in diabetic mice

To observe the effect and mechanism of liraglutide on the expression of key enzymes glucose-6-phosphate (G-6-Pase) and phosphoenolpyruvate carboxylase (PEPCK) in hepatic gluconeogenesis in diabetic mice...

2022-06-23
【Animal Modeling】-Protective effect and mechanism of estrogen on oxidative stress injury of mouse osteoblast MC3T3-E1

【Animal Modeling】-Protective effect and mechanism of estrogen on oxidative stress injury of mouse osteoblast MC3T3-E1

To investigate the protective effect and mechanism of estrogen on mouse osteoblast MC3T3-E1 oxidative stress injury...

2022-06-22
【Animal Model】-Interventional effect of valsartan on the activity of rat glomerular mesangial cells induced by high glucose

【Animal Model】-Interventional effect of valsartan on the activity of rat glomerular mesangial cells induced by high glucose

To investigate the effect and mechanism of valsartan on the proliferation and apoptosis of rat renal cells induced by high glucose...

2022-06-22
【Animal modeling】-The lipid-lowering effect of citrus polymethoxyflavonoid biscuits on hyperlipidemia mice

【Animal modeling】-The lipid-lowering effect of citrus polymethoxyflavonoid biscuits on hyperlipidemia mice

This study was the first to evaluate the lipid-lowering effect of adding citrus polymethoxyflavone powder to biscuits by measuring lipid metabolism experimental indicators in a hyperlipidemia mouse model, aiming to provide a new functional food for d...

2022-06-22
【Animal Modeling】-Effect of ubiquitin carboxyl-terminal hydrolase 1 gene deletion on the reproductive system development of female mice

【Animal Modeling】-Effect of ubiquitin carboxyl-terminal hydrolase 1 gene deletion on the reproductive system development of female mice

To study the effect of ubiquitin carboxyl-terminal hydrolase L1 gene deletion on the reproductive system of female mice...

2022-06-22
【Animal Modeling】-Effects of electroacupuncture on synaptic plasticity and microglia polarization in rats with cerebral ischemia

【Animal Modeling】-Effects of electroacupuncture on synaptic plasticity and microglia polarization in rats with cerebral ischemia

To investigate synaptic plasticity and microglial polarization in rats with focal cerebral ischemia by electroacupuncture, and to detect the expression of miR-21/signal transducer and activator of transcription 3 (STAT3) pathway...

2022-06-22
【Animal modeling】-The effect of paeoniflorin on Bayk8644-induced depression-anxiety-like behavior in rats and its mechanism

【Animal modeling】-The effect of paeoniflorin on Bayk8644-induced depression-anxiety-like behavior in rats and its mechanism

To investigate the pharmacological mechanism of paeoniflorin in improving depression-anxiety-like behavior in rats based on L-type voltage-dependent calcium channel...

2022-06-22
【Animal modeling】-Effect of Tongxinluo capsule on inflammatory response, brain edema and cognitive function in rats exposed to hypobaric hypoxia

【Animal modeling】-Effect of Tongxinluo capsule on inflammatory response, brain edema and cognitive function in rats exposed to hypobaric hypoxia

To investigate the neuroprotective effect of Tongxinluo capsule on cognitive impairment in rats exposed to acute hypobaric hypoxia and its related mechanism...

2022-06-22
【Animal Modeling】-Knockout of Leptin Receptor Causes Activation of Microglia in Rat Brain Tissue

【Animal Modeling】-Knockout of Leptin Receptor Causes Activation of Microglia in Rat Brain Tissue

To analyze the morphological and functional changes of microglia in the brain of leptin receptor (LEPR) knockout rats, and to explore the function of leptin receptor in microglia. effect....

2022-06-22
【Animal Modeling】-Preliminary study on the effect of lipopolysaccharide on the lung tissue of naked mole rats

【Animal Modeling】-Preliminary study on the effect of lipopolysaccharide on the lung tissue of naked mole rats

To observe and analyze the effects of lipopolysaccharide on the morphological structure and pathological indexes of the lungs of naked mole-rats, and to preliminarily explore whether the naked mole-rats have LPS tolerance...

2022-06-22
【Animal modeling】-Effect of Helicobacter hepatica infection on dextran sulfate sodium-induced chronic colitis model in mice

【Animal modeling】-Effect of Helicobacter hepatica infection on dextran sulfate sodium-induced chronic colitis model in mice

To investigate the effect of Helicobacter hepatica infection on chronic colitis induced by sodium dextran sulfate in mice...

2022-06-22