内页大图
【Animal modeling】-Effect of Jiangxiangru water extract on gastrointestinal physiology, biochemistry and immune function in hyperlipidemia rats

【Animal modeling】-Effect of Jiangxiangru water extract on gastrointestinal physiology, biochemistry and immune function in hyperlipidemia rats

To investigate the therapeutic improvement effect of Jiangxiangru water extract on hyperlipidemia model rats, and to provide modern pharmacological basis for the traditional efficacy of Jiangxiangru for warming the stomach, invigorating the spleen an...

2022-06-17
【Animal modeling】-Effect of astragaloside Ⅱ on IL-21/STAT3 pathway and airway inflammation in juvenile asthmatic rats

【Animal modeling】-Effect of astragaloside Ⅱ on IL-21/STAT3 pathway and airway inflammation in juvenile asthmatic rats

To investigate the effect of astragaloside Ⅱ on the interleukin-21 ( IL-21 ) / signal transducer and activator of transcription 3 ( STAT3 ) pathway and airway inflammation in juvenile asthmatic rats...

2022-06-17
【Animal modeling】-Effect of microcystin-LR on mitochondrial function of mouse primary hepatocytes

【Animal modeling】-Effect of microcystin-LR on mitochondrial function of mouse primary hepatocytes

Microcystin contamination caused by cyanobacterial blooms is one of the worldwide concerns. Microcystin LR (MC-LR) has strong specific hepatotoxicity, but its exact mechanism of liver injury has not been fully elucidated. To solve this problem, this ...

2022-06-17
【Animal Modeling】-The effect of carbon tetrachloride-induced acute liver injury on the heart in a rat model

【Animal Modeling】-The effect of carbon tetrachloride-induced acute liver injury on the heart in a rat model

To investigate the effect of carbon tetrachloride (CCl4) on cardiac function and morphology in rats with acute liver injury...

2022-06-17
【Animal Modeling】-Study on the alleviation of exercise via FoxO1-lipophagy pathway. Study on hyperlipidemia in ApoE-/- mice

【Animal Modeling】-Study on the alleviation of exercise via FoxO1-lipophagy pathway. Study on hyperlipidemia in ApoE-/- mice

Lipophagy is a selective autophagy targeting adipose and is regulated by FoxO1. As an effective means of regulating lipid metabolism disorders, there is no report on whether exercise is related to FoxO1-lipophagy process in hyperlipidemia. In this st...

2022-06-17
【Animal Modeling】-Effect of REST/NRSF on depression and anxiety-like behavior in corticosterone stress model mice

【Animal Modeling】-Effect of REST/NRSF on depression and anxiety-like behavior in corticosterone stress model mice

To study the expression of REST in corticosterone model mice and the effect of REST expression on depression and anxiety behavior in mice, and to explore its role in the mouse model of depression...

2022-06-17
【Animal Modeling】-Intervention of Fufang Dihuang Granules on Microglia Activation and Neurobehavior in Parkinson\'s Disease Model Rats

【Animal Modeling】-Intervention of Fufang Dihuang Granules on Microglia Activation and Neurobehavior in Parkinson's Disease Model Rats

To investigate the intervention effect of Fufang Dihuang Granules on the activation of nigrostriatal microglia, the expression of inflammatory factors and neurobehavior in different rat models...

2022-06-17
【Animal Modeling】-Antibiotic-induced microbiome depletion promotes intestinal colonization of Campylobacter jejuni in mice

【Animal Modeling】-Antibiotic-induced microbiome depletion promotes intestinal colonization of Campylobacter jejuni in mice

To establish a method for intestinal colonization of C57BL/6 mice by Campylobacter jejuni through antibiotic-induced gut microbiome depletion...

2022-06-17
【Animal modeling】-Evaluation of the curative effect of Shenling Baizhu powder on ulcerative colitis model mice

【Animal modeling】-Evaluation of the curative effect of Shenling Baizhu powder on ulcerative colitis model mice

To explore the curative effect of Shenling Baizhu powder on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) model mice...

2022-06-17
【Animal modeling】-The improvement effect of Baixiangdan capsule on premenstrual anxiety disorder caused by ovariectomy in rats

【Animal modeling】-The improvement effect of Baixiangdan capsule on premenstrual anxiety disorder caused by ovariectomy in rats

To compare traditional Chinese medicine Baixiangdan Capsules (BXD), serotonin 3 receptor (5-HT3R) specific agonists and their antagonists, cannabinoid receptor 1 (CB1R) specific agonists and their antagonists through a series of behavioral tests. Int...

2022-06-16
【Animal modeling】-Effect and safety of domestic porcine small intestinal submucosa acellular matrix for dura mater repair in rabbits

【Animal modeling】-Effect and safety of domestic porcine small intestinal submucosa acellular matrix for dura mater repair in rabbits

To construct a dural defect model in New Zealand white rabbits, and to evaluate the effectiveness of the biodegradable patch in repairing dural defect by observing the physiological state, clinical manifestations and histopathological changes of the ...

2022-06-16
【Animal modeling】-Observation of the anesthesia effect of different doses of sutai combined with xylazine hydrochloride on C57BL/6J mice

【Animal modeling】-Observation of the anesthesia effect of different doses of sutai combined with xylazine hydrochloride on C57BL/6J mice

To anesthetize C57BL/6J mice with different doses of sutai combined with xylazine hydrochloride, observe the anesthesia-related time of mice under different anesthesia doses, and provide reference for various types of mouse operations and related exp...

2022-06-16
【Animal Modeling】-Anesthesia effect of Shutai and Lumianning compound doses on Bama miniature pigs

【Animal Modeling】-Anesthesia effect of Shutai and Lumianning compound doses on Bama miniature pigs

To study the anesthesia effect of Shutai and Lu Mianning compound anesthesia on Bama miniature pigs, and to preliminarily observe the effect of anesthesia on the physiological indexes of miniature pigs...

2022-06-16
【Animal modeling】-Effect of low expression of lipoic acid synthase on antioxidant capacity in mice

【Animal modeling】-Effect of low expression of lipoic acid synthase on antioxidant capacity in mice

To establish a genetically modified mouse with low expression of lipoic acid synthase gene, and to test its antioxidant capacity...

2022-06-16
【Animal Modeling】-Effects of C. chinensis mediated IκB-α phosphorylation on CCl4-induced hepatic fibrosis in rats

【Animal Modeling】-Effects of C. chinensis mediated IκB-α phosphorylation on CCl4-induced hepatic fibrosis in rats

  Objective To investigate the effect of IκB-α and its phosphorylation to down-regulate the nuclear transcription factor signaling pathway to reduce carbon tetrachloride-induced liver fibrosis in C. chinensis.   Methods The CCl4 liver fibrosis rat...

2022-06-16
【Animal modeling】-Effect of Ginkgo Mihuan oral solution on the angiogenesis ability of myocardial microvascular endothelial cells in rats

【Animal modeling】-Effect of Ginkgo Mihuan oral solution on the angiogenesis ability of myocardial microvascular endothelial cells in rats

To observe the effects of Ginkgo Mihuan oral solution (referred to as Ginkgo biloba) on the proliferation, migration, cell tubule formation and protein expression of VEGF (vascular endothelial growth factor) and CD31 (platelet-endothelial cell adhesi...

2022-06-16