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【Animal Modeling】-The mechanism of mouse germ cell-specific transcription factor SOHLH1 regulating Sox30 gene expression

【Animal Modeling】-The mechanism of mouse germ cell-specific transcription factor SOHLH1 regulating Sox30 gene expression

SOHLH1 and SOX30 are transcription factors related to spermatogenesis. Both Sohlh1 and Sox30 gene knockout male mice lose fertility...

2022-07-01
【Animal Modeling】-The neuroprotective effect of total flavonoids of Mongolian herb Xiangqinglan on Parkinson\\\\

【Animal Modeling】-The neuroprotective effect of total flavonoids of Mongolian herb Xiangqinglan on Parkinson

To investigate the neuroprotective effect of the total flavonoids of Mongolian medicine Xiangqinglan on MPTP-induced Parkinson\\\\\\\'s model mice...

2022-07-01
【Animal Modeling】-Changes and significance of metallothionein expression in the development of hepatocellular carcinoma in C57BL/6J mice

【Animal Modeling】-Changes and significance of metallothionein expression in the development of hepatocellular carcinoma in C57BL/6J mice

To understand the dynamic changes and regularities of gene expression levels of metallothioneins (MTs) in the development of mouse hepatocellular carcinoma (HCC), and to explore the significance of MTs in the development of HCC...

2022-07-01
【Animal modeling】- Breeding and genotype identification of Bmal1 clock gene knockout mice

【Animal modeling】- Breeding and genotype identification of Bmal1 clock gene knockout mice

To breed and identify the genotype of Bmal1 knockout mice to provide an ideal animal model for biological rhythm research...

2022-07-01
【Animal Modeling】-The effect of increasing-dose benzalkonium chloride on rabbit anterior chamber

【Animal Modeling】-The effect of increasing-dose benzalkonium chloride on rabbit anterior chamber

Corneal endothelium (CE) is a layer of cells on the inner surface of the cornea. Its main function is to control the hydration of the cornea, thereby maintaining its transparency...

2022-07-01
【Animal modeling】-Experimental study on the differentiation of bone marrow mesenchymal stem cells into cardiomyocyte-like cells induced by Jiawei Danshen Decoction in vitro

【Animal modeling】-Experimental study on the differentiation of bone marrow mesenchymal stem cells into cardiomyocyte-like cells induced by Jiawei Danshen Decoction in vitro

To investigate the experimental study on the differentiation of bone marrow mesenchymal stem cells into cardiomyocyte-like cells induced by Modified Danshen Decoction in vitro...

2022-07-01
【Animal Modeling】-Effects of chronic arsenic exposure on brain and serum metabolomics in mice

【Animal Modeling】-Effects of chronic arsenic exposure on brain and serum metabolomics in mice

To observe the effects of chronic arsenic exposure on the metabolomics of mouse cortex and serum, and to explore its neurotoxicity mechanism...

2022-07-01
【Animal modeling】-The role of CaN-NFATc3 pathway in restenosis after balloon dilation of abdominal aorta in rats

【Animal modeling】-The role of CaN-NFATc3 pathway in restenosis after balloon dilation of abdominal aorta in rats

To study the role of calcineurin (CaN) and its downstream activated T cell nuclear factor (NFATc3) in restenosis after balloon dilatation, and to provide a new theoretical basis for the prevention and treatment of vascular restenosis...

2022-07-01
【Animal Modeling】-Preparation of Induced Lymphoma

【Animal Modeling】-Preparation of Induced Lymphoma

Animal model of chemically induced lymphoma [modeling mechanism] The most commonly used inducer is N-methylnitrosourea (MNU)...

2022-07-01
【Animal modeling】-Quantitative analysis of liver tumors in BALB/c mutant curly mice based on Image J software

【Animal modeling】-Quantitative analysis of liver tumors in BALB/c mutant curly mice based on Image J software

To investigate the differences between BALB/c mutant curly-haired mice and normal BALB/c mice to construct tumor models via portal vein injection, and to establish a quantitative analysis method of tumor images based on Image J software...

2022-07-01
【Animal Modeling】-Effect of Atractylodes Rhizoma Extract on gastric mucosa and gastrointestinal immune function in rats with spleen deficiency syndrome

【Animal Modeling】-Effect of Atractylodes Rhizoma Extract on gastric mucosa and gastrointestinal immune function in rats with spleen deficiency syndrome

To investigate the protective effect of Atractylodes Rhizoma extract on gastric mucosa and its effect on gastrointestinal immune function in spleen deficiency model rats, and to clarify the mechanism of ERA\\\'s intervention in spleen deficiency synd...

2022-07-01
【Animal Modeling】-A single intraosseous injection of simvastatin promotes normalization of tumor blood vessels in mouse breast cancer

【Animal Modeling】-A single intraosseous injection of simvastatin promotes normalization of tumor blood vessels in mouse breast cancer

To study the effect of a single intraosseous injection of simvastatin on the vascular structure and function of mouse breast cancer tumors...

2022-07-01
【Animal modeling】-Study on the protective effect of morroniside administered 24 hours after operation on focal cerebral ischemia-reperfusion in rats

【Animal modeling】-Study on the protective effect of morroniside administered 24 hours after operation on focal cerebral ischemia-reperfusion in rats

To study the effect of morroniside on angiogenesis-related factors and neurological function 24 hours after focal cerebral ischemia-reperfusion in rats...

2022-07-01
【Animal modeling】-Influence of RNA interference inhibition of Beclin1 gene on proliferation and apoptosis of naked mole rat fibroblasts

【Animal modeling】-Influence of RNA interference inhibition of Beclin1 gene on proliferation and apoptosis of naked mole rat fibroblasts

To inhibit the expression of autophagy-regulating gene Beclin 1 by RNA interference technology, and to detect the effect of Beclin 1 expression on the proliferation and apoptosis of naked mole rat skin fibroblasts and the expression of p53, BAX, Bcl2...

2022-07-01
【Animal Modeling】-Study on the analgesic effect of oxysophocarpine on inflammatory pain in mice

【Animal Modeling】-Study on the analgesic effect of oxysophocarpine on inflammatory pain in mice

To study the effect of oxysophocarpine on xylene and carrageenan-induced inflammatory pain in mice to explore its possible mechanism...

2022-07-01
【Animal Modeling】-Effect of curcumin on intestinal mucosal injury and oxidative stress in rats under the desert heat and dry environment

【Animal Modeling】-Effect of curcumin on intestinal mucosal injury and oxidative stress in rats under the desert heat and dry environment

To investigate the protective effect of curcumin pretreatment on the intestinal mucosa of rats under the dry and hot desert environment...

2022-07-01