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【Animal modeling】-Isolation and identification of mouse CD4+ T cell exosomes

【Animal modeling】-Isolation and identification of mouse CD4+ T cell exosomes

To investigate whether CD4+ T cells have the ability to secrete exosomes, and the possibility of CD4+ T cell exosomes participating in inflammation and tumor immune processes...

2022-07-07
【Animal modeling】-The role of MicroRNA-137 and AngⅡ in cardiac remodeling in spontaneously hypertensive rats

【Animal modeling】-The role of MicroRNA-137 and AngⅡ in cardiac remodeling in spontaneously hypertensive rats

To investigate the role of microribonucleic acid 195 (MicroRNA-137, miRNA-137), TGF-β1/Smads signal transduction pathway and angiotensin II (Ang II) in cardiac remodeling in spontaneously hypertensive rats (SHR)...

2022-07-07
【Animal Modeling】-Lactobacillus rhamnosus culture supernatant prevents Escherichia coli meningitis by inhibiting NF-κB pathway

【Animal Modeling】-Lactobacillus rhamnosus culture supernatant prevents Escherichia coli meningitis by inhibiting NF-κB pathway

To investigate whether Lactobacillus rhamnosus supernatant (LGG-CM) can block bacterial meningitis caused by Escherichia coli K1 (E. coli K1) strain by inhibiting NF-κB pathway in vitro...

2022-07-07
【Animal Modeling】-Inhibition of PAR2-PKA/PKCε pathway in peripheral neurons affects pain threshold in rats with pain transformation

【Animal Modeling】-Inhibition of PAR2-PKA/PKCε pathway in peripheral neurons affects pain threshold in rats with pain transformation

To investigate the role of the peripheral neuron protease-activated receptor 2-protein kinase A/protein kinase Cε (PAR2-PKA/PKCε) pathway in pain transformation, and to find possible solutions to simultaneously intervene in acute pain and chronic pai...

2022-07-07
【Animal modeling】-Effect of curcumin on blood and tissue neutrophils in rats with heat stroke in desert dry heat environment

【Animal modeling】-Effect of curcumin on blood and tissue neutrophils in rats with heat stroke in desert dry heat environment

To investigate the effect of curcumin pretreatment on the changes of blood and tissue neutrophils in rats with heat stroke in desert dry heat environment...

2022-07-07
【Animal Modeling】-Comparison of Histological Observation of Different Sectioning Methods and Staining Methods of Rat Coccyx Intervertebral Disc

【Animal Modeling】-Comparison of Histological Observation of Different Sectioning Methods and Staining Methods of Rat Coccyx Intervertebral Disc

To compare the advantages and disadvantages of different slicing methods and staining methods of rat tail intervertebral disc, and lay a theoretical foundation for the corresponding clinical diagnosis and experimental research...

2022-07-07
【Animal Modeling】-Study on the anxiety-like behavior of rats induced by different stress methods at different time points

【Animal Modeling】-Study on the anxiety-like behavior of rats induced by different stress methods at different time points

To compare the biological characteristics of several different stress methods to establish an anxiety rat model from different time points, and to provide an experimental basis for finding the most suitable modeling method...

2022-07-07
【Animal modeling】Effect of -17βestradiol on propofol-induced apoptosis of cortical neurons

【Animal modeling】Effect of -17βestradiol on propofol-induced apoptosis of cortical neurons

To investigate the effect and mechanism of 17β-estradiol on the apoptosis of primary cultured cortical neurons induced by propofol...

2022-07-07
【Animal model】-Portal hypertension model caused by ligation of the common bile duct

【Animal model】-Portal hypertension model caused by ligation of the common bile duct

Propagation method Pentobarbital sodium (30 mg/kg body weight) was injected intraperitoneally into male Wistar rats weighing 200 to 250 g, and the midline of the abdomen was cut in each layer of the abdominal wall to separate the common bile duct. Cu...

2022-07-07
【Animal modeling】-Analysis of genetic quality of Wistar rat microsatellite DNA population based on group standard T/CALAS 21—2017

【Animal modeling】-Analysis of genetic quality of Wistar rat microsatellite DNA population based on group standard T/CALAS 21—2017

To analyze the genetic quality of Wistar rats in closed groups at different periods by using the method recommended by the group standard T/CALAS 21-2017, and to evaluate the applicability of the group standard T/CALAS 21-2017...

2022-07-07
【Animal modeling】-Evaluation of the detection method of intestinal mucosal barrier damage in diabetic rats and discussion of the hypoglycemic effect of propolis

【Animal modeling】-Evaluation of the detection method of intestinal mucosal barrier damage in diabetic rats and discussion of the hypoglycemic effect of propolis

To analyze and evaluate the detection method of intestinal mucosal barrier function in diabetic rats, and to explore whether propolis exerts hypoglycemic effect by repairing intestinal mucosal barrier...

2022-07-07
【Animal modeling】-PKH26 and Hoechst 33258 combined tracing of Uncv hairless mouse iRhom2 and its mutant proteins

【Animal modeling】-PKH26 and Hoechst 33258 combined tracing of Uncv hairless mouse iRhom2 and its mutant proteins

To use PKH26 and Hoechst 33258 to trace the localization of Uncv hairless mouse iRhom2 and its mutant proteins in Vero cells...

2022-07-07
【Animal modeling】-Establishment of a porcine cornea test for acute eye irritation of a disinfectant

【Animal modeling】-Establishment of a porcine cornea test for acute eye irritation of a disinfectant

To establish an in vitro method for the detection of acute eye irritation of disinfected products using porcine cornea...

2022-07-07
【Animal Modeling】-Aconitine-induced rapid ventricular arrhythmia model

【Animal Modeling】-Aconitine-induced rapid ventricular arrhythmia model

Arrhythmia caused by aconitine is mainly related to inhibiting membrane Na + channel inactivation, promoting continuous Na + influx and improving the autonomy of ectopic pacemakers...

2022-07-07
【Animal Modeling】-Observation of some physiological indicators of rhesus monkeys using implanted telemetry technology

【Animal Modeling】-Observation of some physiological indicators of rhesus monkeys using implanted telemetry technology

To observe the circadian variation of physiological indicators such as respiration, blood pressure, ECG, and body temperature in awake rhesus monkeys with implanted telemetry technology and changes during stress...

2022-07-07
【Animal modeling】-Effect of modified Wuzhuyu decoction on hypertension and vascular endothelial function in rats induced by high sugar, high fat and alcohol consumption

【Animal modeling】-Effect of modified Wuzhuyu decoction on hypertension and vascular endothelial function in rats induced by high sugar, high fat and alcohol consumption

To investigate the effect of modified Wuzhuyu Decoction on blood pressure and vascular endothelial function in hypertensive model rats induced by high-sugar and high-fat diet and drinking...

2022-07-06