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【Animal modeling】-Cloning and molecular characterization of the full-length coding sequence of tree shrew BACE1

【Animal modeling】-Cloning and molecular characterization of the full-length coding sequence of tree shrew BACE1

To obtain the full-length coding sequence of the tree shrew β-amyloid precursor protein cleaving enzyme BACE1 and analyze its molecular characteristics, so as to provide a basis for the research on the mechanism of AD disease...

2022-04-27
【Animal modeling】-Effect of camel milk on glucose and lipid metabolism and PPAR-γ, TNF-α mRNA in type 2 diabetic rats

【Animal modeling】-Effect of camel milk on glucose and lipid metabolism and PPAR-γ, TNF-α mRNA in type 2 diabetic rats

To study the effect of camel milk (CM) on body weight, blood glucose, blood lipid, insulin, PPARγ and TNF-α gene expression in type 2 diabetic rats...

2022-04-27
【Animal Modeling】-Feasibility of Transjugular Liver Biopsy in Miniature Pigs

【Animal Modeling】-Feasibility of Transjugular Liver Biopsy in Miniature Pigs

To investigate the feasibility and safety of transjugular liver biopsy (TJLB) using the LABS 200 intrahepatic biopsy needle set from Cook Company...

2022-04-27
【Animal Modeling】-An overview of experimental methods for depressive behavior in rats and mice

【Animal Modeling】-An overview of experimental methods for depressive behavior in rats and mice

Depression is a common mental disease with high prevalence, high disability rate, and high recurrence rate, and its pathogenesis is complex....

2022-04-27
【Animal modeling】-The expression changes of DR5 and DcR2 in ovarian granulosa cells of rats with polycystic ovary syndrome

【Animal modeling】-The expression changes of DR5 and DcR2 in ovarian granulosa cells of rats with polycystic ovary syndrome

To observe the expression changes of DR5 and DcR2 in ovarian granulosa cells of rats with polycystic ovary syndrome, and to explore the possible mechanism of follicular developmental disorders in rats with PCOS...

2022-04-27
【Animal modeling】-Analysis of echocardiographic examination of Bama miniature pigs under compound anesthesia with Lu Mianning

【Animal modeling】-Analysis of echocardiographic examination of Bama miniature pigs under compound anesthesia with Lu Mianning

To observe the general anesthesia effect of Lu Mianning compound anesthesia on miniature pigs, and to emphasize the safety awareness of general anesthesia. Echocardiography was used to study the main functions and structures of normal minipig hearts...

2022-04-27
【Animal modeling】-Directed editing of mouse MAD2L1 gene based on CRISPR/Cas9 system and analysis of its off-target effect

【Animal modeling】-Directed editing of mouse MAD2L1 gene based on CRISPR/Cas9 system and analysis of its off-target effect

To establish a method system for gene editing of the second exon of mouse MAD2L1 gene using CRISPR/Cas9 system, and to analyze the off-target effect of CRISPR/Cas9 on MAD2L1 gene editing...

2022-04-26
【Animal modeling】-Micro-CT observation of the effect of recombinant human parathyroid hormone on fracture healing in 2-month-old male rats

【Animal modeling】-Micro-CT observation of the effect of recombinant human parathyroid hormone on fracture healing in 2-month-old male rats

To investigate the effect of recombinant human parathyroid hormone (rhPTH) on fracture healing in 2-month-old male rats using Micro-CT...

2022-04-26
【Animal modeling】-Study on differential expression of lysozyme 1 in hatched and dormant blastocysts before and after superovulation in mice

【Animal modeling】-Study on differential expression of lysozyme 1 in hatched and dormant blastocysts before and after superovulation in mice

To study the distribution and expression of lysozyme 1 gene in hatched blastocysts and dormant embryos of mice before and after superovulation, and to explore the new regulatory mechanism of animal embryo implantation...

2022-04-26
【Animal Modeling】-Programmed freezing of hatched blastocysts and their dormant embryos in mice-Differential expression of Mgst1 gene before and after thawing

【Animal Modeling】-Programmed freezing of hatched blastocysts and their dormant embryos in mice-Differential expression of Mgst1 gene before and after thawing

To analyze the role of Mgst1 gene in the programmed freezing of mouse embryos by comparing the relative expression of Mgst1 gene and the differential expression distribution of Mgst1 protein before and after programmed freezing and thawing of hatched...

2022-04-26
【Animal modeling】-The role and mechanism of eNOS/NO pathway in renal interstitial microangiopathy in mice with unilateral ureteral obstruction

【Animal modeling】-The role and mechanism of eNOS/NO pathway in renal interstitial microangiopathy in mice with unilateral ureteral obstruction

To investigate the role and mechanism of endothelial nitric oxide synthase and nitric oxide in microvascular disease in mice with unilateral ureteral obstruction and renal interstitial fibrosis...

2022-04-26
【Animal modeling】-The expression and ultrastructural observation of kidney-yang deficiency-related mRNA in the hypothalamus of Lewis rats

【Animal modeling】-The expression and ultrastructural observation of kidney-yang deficiency-related mRNA in the hypothalamus of Lewis rats

To further study the kidney-yang deficiency constitution of Lewis rats by observing the gene expression and ultrastructure related to kidney-yang deficiency in the hypothalamus of Lewis rats...

2022-04-26
【Animal modeling】-Effect of Naoshuantong capsule on the expression of inflammatory factors in aorta of ApoE-/- mice

【Animal modeling】-Effect of Naoshuantong capsule on the expression of inflammatory factors in aorta of ApoE-/- mice

To observe the effect of Naoshuantong capsule on the expression of inflammatory related factors interleukin-1β, interleukin-6, tumor necrosis factor, intercellular adhesion molecule-1 and metalloproteinase-9 in ApoE-/- atherosclerosis mouse model. Th...

2022-04-26
【Animal modeling】-The role of KA1 subreceptors in the death of hippocampal neurons induced by endoplasmic reticulum stress

【Animal modeling】-The role of KA1 subreceptors in the death of hippocampal neurons induced by endoplasmic reticulum stress

To explore the role of up-regulated expression of KA1 sub-receptors in the death of hippocampal neurons induced by endoplasmic reticulum stress...

2022-04-26
【Animal Modeling】-Improved method to explore and extract rat dorsal root ganglia against the direction of nerve walking

【Animal Modeling】-Improved method to explore and extract rat dorsal root ganglia against the direction of nerve walking

Explore a new method of fast, convenient and efficient extraction of rat dorsal root ganglia (dorsal root ganglion, DRG)-exploring and extracting DRG against the direction of nerve walking...

2022-04-26
【Animal Modeling】-Observation of neurotoxicological effects of flame retardant TCPP exposure in mice and related mechanisms

【Animal Modeling】-Observation of neurotoxicological effects of flame retardant TCPP exposure in mice and related mechanisms

To investigate the neurotoxicological effects of flame retardant TCPP exposure in mice and related mechanisms...

2022-04-26