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【Animal Modeling】-DB11/T828.3-2011 Chromosome 12 Marker Screening and Applicability Evaluation Research

【Animal Modeling】-DB11/T828.3-2011 Chromosome 12 Marker Screening and Applicability Evaluation Research

To screen the vacant chromosome 12 markers in the local standard for genetic quality control of Beijing miniature pigs DB11/T828.3-2011, and to analyze the applicability of landmarks by comparing the genetic evaluation of different markers in the sam...

2022-03-24
【Animal model】-Respiratory system disease

【Animal model】-Respiratory system disease

Rats, guinea pigs or monkeys are often used to inhale irritating gases (such as sulfur dioxide, chlorine, ammonia, smoke, etc.) to replicate human chronic bronchitis. It has been found that the submucosal glands of pigs are similar to humans, and tra...

2022-03-24
【Animal Modeling】-Changes and significance of metallothionein expression in the development of hepatocellular carcinoma in C57BL/6J mice

【Animal Modeling】-Changes and significance of metallothionein expression in the development of hepatocellular carcinoma in C57BL/6J mice

To understand the dynamic changes and regularities of gene expression levels of metallothioneins (MTs) in the development of mouse hepatocellular carcinoma (HCC), and to explore the significance of MTs in the development of HCC...

2022-03-23
【Animal modeling】-Effect of genipin on liver regeneration after partial hepatectomy in ob/ob mice

【Animal modeling】-Effect of genipin on liver regeneration after partial hepatectomy in ob/ob mice

To investigate the changes of liver regeneration after partial hepatectomy in ob/ob mice with genetic deficiency of leptin gene and the effect of genipin on liver regeneration...

2022-03-23
【Animal Modeling】-Animal Model of Nervous System Disease

【Animal Modeling】-Animal Model of Nervous System Disease

The progression of human diseases is very complicated. It is used as an experimental object for humans to explore the mechanism of disease. The process of facilitating drug development is slow...

2022-03-23
【Animal modeling】-Relieving effect of formononetin on osteoporosis in Ⅱ diabetic rats

【Animal modeling】-Relieving effect of formononetin on osteoporosis in Ⅱ diabetic rats

To explore the alleviating effect of formononetin on osteoporosis in rats with type Ⅱ diabetes complicated with diabetic bone disease...

2022-03-23
【Animal Modeling】-Prophylactic use of trigonelline reduces symptoms in a rat model of pregnancy-induced hypertension and protects fetal growth and vascular endothelial function

【Animal Modeling】-Prophylactic use of trigonelline reduces symptoms in a rat model of pregnancy-induced hypertension and protects fetal growth and vascular endothelial function

To determine the therapeutic effect of trigonelline in early pregnancy in rats with PE induced by the nitric oxide synthase antagonist N-nitro-1-arginine methyl ester (LNAME)...

2022-03-23
[Animal modeling]-Inhibitory effect of atrial natriuretic peptide on the growth of transplanted melanoma in gene knockout mice

[Animal modeling]-Inhibitory effect of atrial natriuretic peptide on the growth of transplanted melanoma in gene knockout mice

How to study the effect of atrial natriuretic peptide on the growth of melanoma...

2022-03-23
【Animal Modeling】-Effect of geranin on meconium-induced acute lung injury in neonatal rats and its mechanism

【Animal Modeling】-Effect of geranin on meconium-induced acute lung injury in neonatal rats and its mechanism

To investigate the effect of geranin on meconium-induced acute lung injury in neonatal rats and its molecular mechanism...

2022-03-23
【Animal modeling】-Changes of IL-6, SOD and MDA in the lung tissue of rats with acute pulmonary edema

【Animal modeling】-Changes of IL-6, SOD and MDA in the lung tissue of rats with acute pulmonary edema

To investigate the changes and significance of malondialdehyde, superoxide dismutase and interleukin-6 in lung tissue of acute hypoxia-induced acute pulmonary edema in rats...

2022-03-23
【Animal modeling】-Astragalus polysaccharide regulates Sirt1/FoxO1 pathway and inhibits autophagy in granulosa cells of rats with polycystic ovary syndrome

【Animal modeling】-Astragalus polysaccharide regulates Sirt1/FoxO1 pathway and inhibits autophagy in granulosa cells of rats with polycystic ovary syndrome

To investigate the effect of astragalus polysaccharide (APS) regulating the silent information regulator 1/forkhead transcription factor O1 ( Sirt1 / FoxO1) pathway on autophagy in granulosa cells of polycystic ovary syndrome (PCOS) rats...

2022-03-23
【Animal Modeling】-Evaluation of the effect of midazolam and butorphanol on anesthesia in mice before isoflurane anesthesia

【Animal Modeling】-Evaluation of the effect of midazolam and butorphanol on anesthesia in mice before isoflurane anesthesia

To observe the anesthesia effect and internal environment stability of mice receiving midazolam combined with butorphanol before isoflurane anesthesia, and evaluate the safety...

2022-03-23
【Animal Modeling】-Effect of Protein Phosphatase 5 (PP5) on Fat Metabolism in Mice

【Animal Modeling】-Effect of Protein Phosphatase 5 (PP5) on Fat Metabolism in Mice

To explore the role of PP5 in fat metabolism in mice using protein phosphatase 5 (PP5) knockout mice...

2022-03-23
【Animal Modeling】-Miniature Pig Model of Spontaneous Periodontitis

【Animal Modeling】-Miniature Pig Model of Spontaneous Periodontitis

Spontaneous gingivitis spreads in the mouth of miniature pigs, and a large amount of food residues are often left on the edge of the gums after eating, so the periodontal tissue is not clean, and dental plaque and stones are easy to form...

2022-03-23
【Animal modeling】-Establishment and application of a method for detecting the copy number of porcine endogenous retrovirus based on droplet digital PCR technology

【Animal modeling】-Establishment and application of a method for detecting the copy number of porcine endogenous retrovirus based on droplet digital PCR technology

To optimize the detection method of porcine endogenous retrovirus copy number in pig genome by using droplet digital PCR technology, and to establish a detection method for PERV copy number...

2022-03-23
【Animal Modeling】-Anti-depressant effect of luteolin on chronic unpredictable mild stress mice

【Animal Modeling】-Anti-depressant effect of luteolin on chronic unpredictable mild stress mice

To observe the effect of hyaluronan on antidepressant, and to preliminarily explore its possible mechanism of action...

2022-03-22