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【Animal modeling】-Flow cytometry analysis of the phenotypic characteristics of PMA-induced THP-1 differentiation into macrophages

【Animal modeling】-Flow cytometry analysis of the phenotypic characteristics of PMA-induced THP-1 differentiation into macrophages

To clarify the differentiation of macrophages derived from THP-1 cells induced by PMA alone by flow cytometry...

2022-03-30
【Animal Modeling】-Effects of Vanadium Exposure on Inflammatory Response and Migration of Rat Microglia

【Animal Modeling】-Effects of Vanadium Exposure on Inflammatory Response and Migration of Rat Microglia

To observe the effects of sodium metavanadate (NaVO3·2H2O) exposure on the inflammatory response and migration of microglia, and to explore the related mechanism of vanadium neurotoxicity...

2022-03-30
【Animal Modeling】-Effects of intermedia and adrenomedullin on cerebral microcirculation in rats with focal cerebral ischemia

【Animal Modeling】-Effects of intermedia and adrenomedullin on cerebral microcirculation in rats with focal cerebral ischemia

To investigate the effects of intermedin and adrenomedullin on cerebral microcirculation in rats with focal cerebral ischemia...

2022-03-29
【Animal modeling】-Effect of Tempol on NF-κB signaling pathway in myocardial hypertrophy rats

【Animal modeling】-Effect of Tempol on NF-κB signaling pathway in myocardial hypertrophy rats

To investigate the effect of 2, 2, 6, 6-tetramethyl-4-piperidinol (temPol) on NF-κB signaling pathway in rat cardiac hypertrophy?...

2022-03-29
【Animal modeling】-Comparison of dopamine content in the lateral geniculate body of guinea pigs with flash-induced myopia and form deprivation myopia

【Animal modeling】-Comparison of dopamine content in the lateral geniculate body of guinea pigs with flash-induced myopia and form deprivation myopia

To observe the changes of dopamine (DA) content in the lateral geniculate body in guinea pig models of flicker-induced myopia and form deprivation myopia, and to conduct a comparative analysis, and to preliminarily explore the central pathogenesis of...

2022-03-29
【Animal Modeling】-Effect of high-fat diet feeding time on type 2 diabetic nephropathy rat model

【Animal Modeling】-Effect of high-fat diet feeding time on type 2 diabetic nephropathy rat model

To explore the effects of different high-fat diet feeding time on blood glucose, insulin resistance index (HOMA-IR) and urinary albumin excretion rate (UAER) in induced type 2 diabetic nephropathy (DN) rat model...

2022-03-29
【Animal modeling】-The effect of TRPV4 receptor on angiotensin II-induced renal damage in mice

【Animal modeling】-The effect of TRPV4 receptor on angiotensin II-induced renal damage in mice

To investigate the role of TRPV4 receptor in angiotensin II-induced renal damage by using transient receptor potential vanilloid 4 knockout (TRPV4 - / - ) mice...

2022-03-29
【Animal modeling】-Effect of botulinum toxin type A heavy chain intervention on the expression of growth-related proteins after spinal cord injury in rats

【Animal modeling】-Effect of botulinum toxin type A heavy chain intervention on the expression of growth-related proteins after spinal cord injury in rats

To investigate the effect of artificial recombinant botulinum toxin type A heavy chain (BoNT/A heavy chain) on the expression of local growth-related proteins in rats with spinal cord injury in vivo, and to provide a basis for elucidating the mechani...

2022-03-29
【Animal modeling】-Effect of vitamin D deficiency on the pathogenesis of spontaneously diabetic rats

【Animal modeling】-Effect of vitamin D deficiency on the pathogenesis of spontaneously diabetic rats

To investigate the effect of vitamin D (VD) deficiency on the pathogenesis of spontaneous diabetic rats...

2022-03-29
【Animal Modeling】-Injury effect of high-frequency electromagnetic radiation on emotion-cognitive behavior in mice

【Animal Modeling】-Injury effect of high-frequency electromagnetic radiation on emotion-cognitive behavior in mice

To explore the establishment of a model of mouse emotional-cognitive behavioral damage caused by high-frequency electromagnetic radiation, and to provide an experimental basis for the study of radiation damage mechanism and protection...

2022-03-29
【Animal Modeling】-Comparison of Transparency of Six Optical Transparency Methods in Rat Brain Tissue Blocks

【Animal Modeling】-Comparison of Transparency of Six Optical Transparency Methods in Rat Brain Tissue Blocks

To compare the transparent effects of six optical clearing methods on rat brain tissue blocks...

2022-03-29
【Animal Modeling】-Using TaqMan probe fluorescence quantitative PCR technology to identify the genotype of Leprdb/+ mice offspring

【Animal Modeling】-Using TaqMan probe fluorescence quantitative PCR technology to identify the genotype of Leprdb/+ mice offspring

To establish an efficient method for genotyping the offspring of Leprdb/ + mice using TaqMan probe fluorescence quantitative PCR technology...

2022-03-29
【Animal modeling】-Blocking macrophage-mediated PD1/PD-L1 pathway inhibits tuberculosis recurrence in mice

【Animal modeling】-Blocking macrophage-mediated PD1/PD-L1 pathway inhibits tuberculosis recurrence in mice

To block the macrophage-mediated PD1/PD-L1 pathway with functional PD-L1 monoclonal antibody, and to study its immune intervention effect and mechanism on the relapse of tuberculosis in mice after treatment...

2022-03-29
【Animal Modeling】-Experimental Study of Riboflavin and Ultraviolet Irradiation in Preventing Progressive Myopia in Guinea Pigs

【Animal Modeling】-Experimental Study of Riboflavin and Ultraviolet Irradiation in Preventing Progressive Myopia in Guinea Pigs

Myopia, especially high myopia, is associated with major eye diseases that ultimately lead to blindness, such as exudative myopic macular degeneration, rhegmatogenous retinal detachment, myopic retinopathy, and glaucoma. The mechanism of myopia is no...

2022-03-28
【Animal Modeling】-Effect of 4-week ladder-climbing resistance training on hypoxia-induced skeletal muscle atrophy in rats

【Animal Modeling】-Effect of 4-week ladder-climbing resistance training on hypoxia-induced skeletal muscle atrophy in rats

To explore the effect of resistance training against hypoxia-induced skeletal muscle atrophy, and to provide a theoretical basis for solving the problem of skeletal muscle loss in athletes during altitude training...

2022-03-28
【Animal modeling】-The protective effect of mild hypothermia on radiation-induced lung injury in rats

【Animal modeling】-The protective effect of mild hypothermia on radiation-induced lung injury in rats

To investigate the protective effect of mild hypothermia on radiation-induced lung injury, and to compare the protective effect with amifostine, a commonly used clinical anti-radiation drug...

2022-03-28