Gene characteristics of placental membrane cells determine the chance of preterm birth

In a recent study, the Dimes Preterm Birth Research Center, led by researchers from the University of Chicago, conducted a new study that found new genetic markers related to gestational age and provided new insights into potential risk factors for p...

2021-02-10

CRISPR-Cas9 technology can effectively treat sickle cell anemia and β-thalassemia

Sickle cell anemia (SCD) and β-thalassemia (TDT) are two common gene-deficient diseases. The common feature is that the globin gene defect causes the synthesis of one or more of the globin peptide chains in hemoglobin to decrease Or cannot be synthes...

2021-02-10

Research reveals a neurological disease similar to Parkinson's

A collaborative study between the National Institute of Neuroscience (NNI) and Singapore General Hospital (SGH) shows that patients diagnosed with Parkinson’s disease may actually have NIID...

2021-02-10

Gene therapy PBGM01 was approved by EMA orphan drug for the treatment of GM1 gangliosidosis

Focusing on the development of single gene conversion therapy for rare central nervous system diseases, the European Commission (EC) has led the treatment of GM1 gangliosidosis in the company on the 26th...

2021-02-10

[Animal modeling]-Observation of the effect of thrombopoietin on cardiomyocyte apoptosis in rats with adriamycin-induced heart failure based on the TGF-β1/Smad3 signaling pathway

To explore the effect of thrombopoietin (TPO) on adriamycin-induced heart failure (CHF) rat cardiomyocyte apoptosis and its regulatory mechanism on TGF-β1/Smad3 signal...

2021-02-07

【Animal Modeling】-The effect of umbilical cord mesenchymal stem cells on the expression of sex hormones, CYR61 and CTGF in premature ovarian failure rabbits

To explore the effects of umbilical cord mesenchymal stem cells on the expression of sex hormones, CYR61 and CTGF in premature ovarian failure rabbits, and reveal their therapeutic effects and their underlying mechanisms...

2021-02-07

【Animal Modeling】-The effect of hypoxic training on Ghrelin￣GHSR pathway in obese mice

Hypoxic training was applied to obese mice to observe the changes of Ghrelin and hypothalamic GHSR levels in gastric tissue to explore whether hypoxic training affects Ghrelin￣GHSR pathway to improve obesity physique...

2021-02-07

[Animal Modeling]-Explore the protective effect and mechanism of activated protein C on myocardial ischemia-reperfusion injury in rats

To explore the protective effect and mechanism of activated protein C (APC) on myocardial ischemia-reperfusion injury in rats...

2021-02-07

Using ECG implants to compare the effects of five general anesthetics on the heart rate of SD rats

Using ECG implants to compare the effects of five general anesthetics on the heart rate of SD rats...

2021-02-07

【Animal Modeling】-Effects of different exercise interventions on emotional behavior of aggressive rats

To explore the influence of different exercise methods on the emotional behavior of aggressive rats...

2021-02-07

【Animal Modeling】-The effect of nicotine on the plasticity of pain threshold in rats with myocardial infarction and its cardioprotection

Observe the plasticity of pain threshold in rats with myocardial infarction, explore the effect of nicotine on visceral pain and whether it has a protective effect on ischemic myocardium...

2021-02-07

[Animal modeling]-The protective effect of aerobic exercise combined with paeonol PLGA nanoparticles on obese rats with hyperlipidemia

　　To explore the effects of aerobic exercise combined with paeonol PLGA nanoparticles on blood biochemistry and lipid metabolism in obese rats with hyperlipidemia...

2021-02-07

[Animal Modeling]-Biosafety and data quality considerations for animal experiments on highly infectious drugs in the ABSL-3 facility

Animal models are the key to the study of serious infectious diseases, and are of great significance for determining the pathogenesis of diseases and developing vaccines and drugs...

2021-02-07

【Animal Modeling】-The effect of high-fat diet induced obesity on ovarian function in female fertile rats

How to evaluate the effect of high-fat diet-induced obesity on ovarian function in female rats and its mechanism?...

2021-02-04

【Animal Modeling】-The protective effect of trigonelline on heat stress-induced damage to the testis of mice

Study the protective effect of triamcinolone on testicular damage in heat-stressed mice?...

2021-02-04

【Animal Modeling】-The effect of acute exercise on the expression of miRNA-30a in rat myocardium

To study the effects of acute exercise on rat myocardial miRNA-30a and the expression of autophagy-related genes, and explore the regulatory mechanism of miRNA-30a on myocardial autophagy activity at different recovery periods after exercise...

2021-02-04