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Using established lymphoma cell lines or patient lymphoma tissues transplanted into immunodeficient animals, transplanted lymphoma models can be established and tumor characteristics can be characterized....
2020-07-31The most commonly used inducer is N-methylnitrosourea (MNU). Its carcinogenic mechanism is related to the formation of O6-methylguanine, which causes GyA point mutations during DNA replication...
2020-07-31By cloning and analyzing the promoter sequence and function of the mouse Tec gene, the genes controlled by the Tec promoter are only specifically expressed in the cytoplasm of hematopoietic stem cells...
2020-07-31Hyperuricemia is caused by a variety of reasons, including excessive uric acid production and/or reduced renal uric acid excretion, leading to supersaturation of urate levels in the extracellular fluid. For men and postmenopausal women, if the blood ...
2020-07-31Long-term stimulation with estrogen can induce PRL tumors in the pituitary gland in rats, but the specific mechanism has not been fully elucidated. For example, after long-term administration of estrogen to F344 rats, the glands may grow abnormally i...
2020-07-31Spontaneously diabetic animals, also called spontaneously hyperglycemic animals, are naturally occurring diabetic animals or diabetic models preserved through genetic breeding and culture, and their performance is the same as that of human diabetic a...
2020-07-31Chronic non-bacterial prostatitis can be caused by mycoplasma, chlamydia and autoimmune diseases. The clinical manifestations of chronic bacterial prostatitis are very similar, but not specific. The main symptoms are urgency, dysuria and urine. Local...
2020-07-31At present, the animal models of hepatitis B virus mainly include sh hepatitis B model, duck hepatitis B model, marmot hepatitis B model and mouse hepatitis B model...
2020-07-31With the continuous deepening of oncogene research, the application of transgenic technology in oncology has become more and more extensive...
2020-07-31Thrombus is formed in the peripheral blood vessels, the emboli flow through the blood and reach the pulmonary artery, blocking the pulmonary artery and forming an embolus....
2020-07-30Objective: To use lithium chloride-pilocarpine to prepare a Wistar rat epilepsy model, and to study the appropriate dosage and usage of pilocarpine. Methods: Wistar rats were injected intraperitoneally with 3 mmol/kg lithium chloride, and 24 hours la...
2020-07-29Under awakening local anesthesia, newborn rats ligate the right common carotid artery and place it in a constant temperature airtight glass container with 8% oxygen +...
2020-07-29For different experimental purposes, different arrhythmias can be reproduced in the whole animal. Alternatively, arrhythmia can be reproduced by in vitro perfusion of an isolated heart or a specific part of the heart. There are several commonly used ...
2020-07-29The animal model of pancreatitis is the best way to study the etiology of pancreatitis and explore clinical treatment methods. However, since the cause of pancreatitis varies with the type of pancreatitis, the cause of pancreatitis is still unknown, ...
2020-07-29In order to simulate human PD, an ideal animal model should have the following characteristics: (1) The number and morphology of dopaminergic neurons at birth are normal, with more than 50% decreasing, young people can easily pass neurochemical react...
2020-07-29In the animal laboratory, living mice and rats can be described as stars, and successful mouse models can be called \"good helpers for life sciences.\" Many people may want to design or understand conditional knockout mice by themselves...
2020-07-29