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The skin is the main organ for human fungus invasion. When limited to skin infections, it only exists on a surface area of 1-2 mm. The main pathogens of superficial skin fungal infections include epidermis, microspores and ringworm. Guinea pigs are s...
2020-08-04Simple herpes simplex virus (herpes simplex virus, HSV) is a cultivable DNA virus, which is classified into HSV1 and HSV2 according to its different antigenic characteristics. Different animal models can be formed under different conditions, such as ...
2020-08-04Many genes are involved in the pathogenesis of SCC. Transgenic animal models with high specific gene expression or no specific gene expression can induce SCC spontaneously or through external factors...
2020-08-04Inoculation of human SCC tissue or cancer cells on the back, armpit, groin, lateral chest wall or sublingual of immunodeficient mice may produce SCC locally...
2020-08-044-nitroquinoline-1-oxide (4-nitroquinoline-1-oxide, 4NQO) is the precursor of carcinogen 4-hydroxyaminoquinoline in the body of 4NQO reductase...
2020-08-04At present, it is believed that the cause of BCC is mainly related to the abnormal activation of the Shh signaling pathway (sonichedgehog signaling pathway, Shh)...
2020-08-04![[Animal model]-Spontaneous basal cell carcinoma model](/./uploads/images/20200804/5f2907a64841f.jpg)
Basal cell carcinoma (BCC) may be derived from primitive epithelial germ cells and is mainly composed of mesenchymal-dependent pluripotent basal-like cells. It is a low-grade malignant tumor that differentiates into the epidermis or accessory organs....
2020-08-04UV-induced melanoma model, some species will develop UV-induced melanoma lesions based on a specific genetic background...
2020-08-04Certain species may spontaneously develop melanoma lesions due to their specific genetic background...
2020-08-04Transgenic mice are valuable tools to determine the physiological functions of specific genes or proteins and their role in pathology. From a unique point of view that helps to study the cause of the disease, various transgenic mice exhibit disease c...
2020-08-04Peroxide Hydrogen peroxide, hydroquinone, monobenzophenone and other skin bleaching agents are used to artificially cause animal bleaching and simulate the pathological symptoms of vitiligo...
2020-08-04Some animals (chickens, rodents, dogs, cats, horses, etc.) can locally cause pigmentation. There are many anti-melanocyte antibodies in these animals, the most commonly used are Smith Line (SL) chickens and C57BL mice...
2020-08-04The specific cause of psoriasis has not been fully clarified, but more and more evidence supports the role of T lymphocytes in it...
2020-08-04Due to uncontrolled and massive proliferation of osteoblasts, osteosarcoma is the most common type of bone tumor...
2020-08-04Nude mice are usually inoculated with tumor mass or cells subcutaneously, and the tumor continues to grow. It can simulate the process of human malignant tumors. The tumor formation rate is high, the tumor formation time is uniform, and the tumor siz...
2020-08-04Allogeneic transplantation refers to the process of transplanting to animals of the same species or the same family. The organisms between the donor and the recipient have a high degree of commonality, and can stay in the body, grow and proliferate, ...
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