【Animal modeling】-Subacute inhalation toxicity study of ivermectin original drug in rats

To study the subacute inhalation toxicity of ivermectin original drug to rats, and to find the maximum ineffective dose...

2022-04-07

【Animal modeling】-Protective effect of Nrf2 antioxidant pathway in CCl4-induced acute liver injury in rats

To study the protective effect of Nrf2 oxidative damage pathway in CCl4-induced acute liver injury in rats...

2022-04-07

【Animal Modeling】-Effect of DPP4 inhibitor sitagliptin on the expression of Egr-1 and FN in the kidney of ApoE knockout mice

To observe the effect of DPP4 inhibitor sitagliptin on the expression of early growth response factor-1 (Egr-1) and fibronectin (FN) in kidney tissue of ApoE knockout mice...

2022-04-06

【Animal modeling】-Mechanism of recombinant adenovirus-mediated adiponectin gene on atherosclerosis in ApoE-/- mice

To study the inhibitory effect of adenovirus-mediated adiponectin (APN) overexpression on atherosclerosis (AS) in ApoE-/- mice and its effect on NF-κB signaling pathway...

2022-04-06

【Animal Modeling】-Effect of continuous multiple application of propofol and vitamin C on anesthesia in mice

To investigate the anesthesia effect of propofol or propofol combined with vitamin C on mice for 6 consecutive days...

2022-04-03

【Animal modeling】-Effect of dexmedetomidine pretreatment on inflammatory factors and oxidative stress in rats with septic kidney injury

To investigate the effect of dexmedetomidine on inflammatory factors and oxidative stress of AKI (acute kidney injury) in septic rats...

2022-04-03

【Animal Modeling】-Vitamin C enhances the proliferation of BMSCs derived from aging individuals in SAMP6 mice

To observe whether vitamin C (Vc) can promote the proliferation of bone marrow mesenchymal stem cells (BMMSCs) derived from aging individuals by increasing telomerase activity...

2022-04-03

【Animal modeling】The effect and mechanism of -2,3-butanedione monooxime in improving abnormal calcium injury in isolated rat heart

To investigate the effect and mechanism of contracture inhibitor 2,3-butanedione monooxime in improving abnormal calcium injury in isolated rat hearts...

2022-04-03

【Animal Modeling】-Continuous 5-day REM sleep deprivation induces delayed-onset depression-like behavior in mice

To investigate the effect of continuous long-term rapid eye movement sleep deprivation (5 d) on depression-like behavior and the level of amygdala monoamine oxidase A in C57BL/6J mice...

2022-04-03

【Animal modeling】-Repair of peripheral nerve defect in rats with chitosan catheter combined with simvastatin/poloxamer 407 hydrogel

To explore the feasibility of chitosan catheter combined with simvastatin/poloxamer 407 hydrogel as acellular artificial nerve scaffold to repair sciatic nerve defect...

2022-04-03

【Animal modeling】-The role of phosphokinase Czeta in the anterior cingulate cortex in emotional responses in rats with inflammatory pain induced by Freund's safety adjuvant

To observe the emotional response of CFA-induced inflammatory pain model rats, and to explore the relationship between the anterior cingulate cortex (ACC) phosphokinase Czeta (PKCzeta) and the emotional response of inflammatory pain rats...

2022-04-02

【Animal modeling】-Proliferation and differentiation of endogenous neural stem cells in the subventricular zone after traumatic brain injury in rats

To investigate the time course changes of the proliferation and differentiation of neural stem cells (NSCs) in the subventricular zone (SVZ) after traumatic brain injury...

2022-04-02

【Animal Modeling】-Effect of Protein Phosphatase 5 (PP5) on Fat Metabolism in Mice

To explore the role of PP5 in fat metabolism in mice using protein phosphatase 5 (PP5) knockout mice...

2022-04-02

【Animal Modeling】-Study on the synergistic analgesic effect of choline and parecoxib sodium and its mechanism through mouse experiments

To investigate the interaction between choline and parecoxib sodium in analgesia and to conduct a preliminary study on its mechanism...

2022-04-01

【Animal Modeling】-Effects of benzene pollution on liver and kidney function and blood nucleotide levels in rats

To explore the effect of benzene on liver and kidney function and blood nucleotide levels in Wistar rats...

2022-04-01

【Animal modeling】-The effect of long-term consumption of Polygonum multiflorum on the hematopoietic system of mice

To investigate the changes of mouse hematopoietic system after long-term consumption of Polygonum multiflorum...

2022-04-01