【Animal modeling】-Effect of repeated restraint and blood collection on cardiac troponin in rats, dogs and cynomolgus monkeys

Cardiac troponins (cTnT and cTnI) serve as clinical blood biomarkers for myocardial injury such as myocardial infarction because of their high diagnostic sensitivity and tissue specificity...

2022-04-13

【Animal modeling】-The protective effect of Jiedu Quyu Zishen Decoction on the kidneys of MRL/lpr lupus mice by intervening TLR9 signaling pathway

Based on the intervention effect on TLR9-MyD88-NF-κB pathway, to clarify the protective effect of Jiedu Quyu Zishen Decoction on the kidneys of lupus mice...

2022-04-12

【Animal modeling】-The protective effect of Danggui Buxue decoction on radiation-injured mice

To observe the protective effect of Danggui Buxue Decoction on mice irradiated by 60C0-γ ray...

2022-04-12

【Animal Modeling】-Establishment of a real-time quantitative PCR detection method for Helicobacter bilis

To establish a rapid, sensitive and specific TaqMan probe real-time quantitative PCR detection method for Helicobacter bilis to quantitatively detect Helicobacter bilis...

2022-04-12

【Animal Modeling】-Genetic Screening of Mutants with Defective Digestive Organ Development in Zebrafish

To genetically screen zebrafish mutants with defective liver, intestine and gallbladder development...

2022-04-12

【Animal Modeling】-Analysis of basic physiological and biochemical indicators of male and female FMMU albino guinea pigs

To measure and compare the blood indexes, heart rate, common carotid arterial pressure, ventricular pressure and organ parameters of female and male common-grade FMMU albino guinea pigs...

2022-04-11

【Animal modeling】-Effect of sesame oil on the expression of insulin sensitivity-related genes in skeletal muscle of insulin-resistant rats

To investigate the effect of a high-fat diet of thulia oil rich in n-3 polyunsaturated fatty acids on insulin sensitivity and the expression of related genes in insulin-resistant rats...

2022-04-11

【Animal modeling】-Influence of RNA interference inhibition of Beclin1 gene on proliferation and apoptosis of naked mole rat fibroblasts

To inhibit the expression of autophagy-regulating gene Beclin 1 by RNA interference technology, and to detect the effect of Beclin 1 expression on the proliferation and apoptosis of naked mole rat skin fibroblasts and the expression of p53, BAX, Bcl2...

2022-04-11

【Animal modeling】-Effect of morroniside on the expression of TIMP in the cortex of ischemia-reperfusion rats

To study the effect of morroniside on the expression of tissue inhibitor of metalloproteinases in the cortex of rats with ischemia-reperfusion for 7 days...

2022-04-11

【Animal Model】-Effect of chronic administration of corticosterone on depression-like behavior and synaptophysin in mice

To observe the effects of corticosterone on depressive-like behavior and hippocampal synaptophysin in animals by chronic administration of corticosterone...

2022-04-11

【Animal Modeling】-Effect of low molecular weight heparin sodium adjuvant on the humoral immune response induced by hepatitis A virus vaccine in mice

To investigate the effect of low molecular weight heparin sodium adjuvant on the humoral immune response induced by hepatitis A virus vaccine in mice...

2022-04-11

【Animal modeling】-Study on the protective effect of Ginkgo biloba extract on MPTP-induced Parkinson's mice

To observe the preventive effect of Ginkgo biloba extract on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson\'s mice of different ages...

2022-04-11

【Animal Modeling】-High-fat and high-purine diet combined with potassium oxonate induces glucose and lipid metabolism disorder and its complications in quail

To establish a practical animal model of chronic metabolic diseases, and to explore the correlation between hyperuricemia and glucose and lipid metabolism, as well as its pathological damage mechanism...

2022-04-11

【Animal modeling】-Pathological observation of renal artery embolism by microsphere embolization agent in Beagle dogs

To establish a model of canine renal artery embolism with microsphere embolization agent, and to evaluate the effect of canine unilateral renal artery embolization and local tissue observation...

2022-04-11

【Animal Modeling】-Effect of natural mountain spring water on SOD and MDA content in aged mice

To investigate the effect of natural mountain spring water on lipid peroxidation in aged mice...

2022-04-09

【Animal Modeling】-Influence of insufficient blood volume in SD rat specimens on the results of four coagulation tests

To investigate the optimal anticoagulation ratio of rats, and to analyze the influence of insufficient blood volume on the four test results of coagulation...

2022-04-09