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【Animal Modeling】-Deletion of MD1 increases the susceptibility to ventricular arrhythmia in obese mice by activating the TLR4/MyD88 signaling pathway

【Animal Modeling】-Deletion of MD1 increases the susceptibility to ventricular arrhythmia in obese mice by activating the TLR4/MyD88 signaling pathway

To investigate the deletion of myeloid differentiation protein 1 (MD1) increases the susceptibility of ventricular arrhythmia in obese mice by activating Toll-like receptor 4 (TLR4)/myeloid differentiation factor (MyD88) signaling pathway...

2022-03-21
【Animal Modeling】-Effects of intermedia and adrenomedullin on cerebral microcirculation in rats with focal cerebral ischemia

【Animal Modeling】-Effects of intermedia and adrenomedullin on cerebral microcirculation in rats with focal cerebral ischemia

To investigate the effects of intermedin and adrenomedullin on cerebral microcirculation in rats with focal cerebral ischemia...

2022-03-19
【Animal Modeling】-Developmental Toxicity of Intravenous Cyclophosphamide on New Zealand Rabbit Embryos and Fetuses

【Animal Modeling】-Developmental Toxicity of Intravenous Cyclophosphamide on New Zealand Rabbit Embryos and Fetuses

To give cyclophosphamide intravenously to pregnant rabbits to observe its toxicity and performance on embryos and fetuses of pregnant rabbits, and to provide reference for selecting cyclophosphamide as a positive control...

2022-03-19
【Animal Modeling】-Study on the effect of vepromide combined with fluoxetine hydrochloride on depressive mice

【Animal Modeling】-Study on the effect of vepromide combined with fluoxetine hydrochloride on depressive mice

To investigate the effect of Weipronamine capsules combined with fluoxetine hydrochloride capsules on depression in mice...

2022-03-19
【Animal Modeling】-Construction and identification of an immunohumanized mouse model of prostate cancer

【Animal Modeling】-Construction and identification of an immunohumanized mouse model of prostate cancer

To construct a mouse model of humanized immune system and transplant it into human prostate cancer cell lines, so as to be used for the research of prostate cancer immunotherapy drugs...

2022-03-19
【Animal Modeling】-Effect of Naoshuantong Capsule on blood lipid levels in atherosclerotic mice

【Animal Modeling】-Effect of Naoshuantong Capsule on blood lipid levels in atherosclerotic mice

To observe the effect of Naoshuantong Capsule on blood lipid levels in atherosclerotic mice, and to explore the mechanism of Naoshuantong Capsule in the treatment of stroke...

2022-03-19
【Animal Modeling】-Construction and identification of an immunohumanized mouse model of prostate cancer

【Animal Modeling】-Construction and identification of an immunohumanized mouse model of prostate cancer

To construct a mouse model of humanized immune system and transplant it into human prostate cancer cell lines, so as to be used for the research of prostate cancer immunotherapy drugs...

2022-03-18
【Animal Modeling】-Based on the Rho/Rho-kinase signaling pathway to investigate the effect of propofol on reducing cerebral ischemia-reperfusion injury in rats

【Animal Modeling】-Based on the Rho/Rho-kinase signaling pathway to investigate the effect of propofol on reducing cerebral ischemia-reperfusion injury in rats

To investigate the effect of propofol on reducing cerebral ischemia-reperfusion injury in rats based on Rho/Rho-kinase signaling pathway...

2022-03-18
【Animal Modeling】-The effect of human umbilical cord mesenchymal stem cells on the level of autophagy in the hippocampus of natural aging rats

【Animal Modeling】-The effect of human umbilical cord mesenchymal stem cells on the level of autophagy in the hippocampus of natural aging rats

To investigate whether transplantation of human umbilical cord mesenchymal stem cells can improve learning and memory and cognitive decline by regulating the level of autophagy in naturally aging rats...

2022-03-18
【Animal modeling】-The lipid-lowering effect of citrus polymethoxyflavonoid biscuits on hyperlipidemia mice

【Animal modeling】-The lipid-lowering effect of citrus polymethoxyflavonoid biscuits on hyperlipidemia mice

This study was the first to evaluate the lipid-lowering effect of adding citrus polymethoxyflavone powder to biscuits in a hyperlipidemia mouse model through the measurement of lipid metabolism experimental indicators, aiming to provide a new functio...

2022-03-18
【Animal modeling】-Effect and mechanism of Shenqu Xiaoshi oral liquid on gastrointestinal motility in mice with functional dyspepsia

【Animal modeling】-Effect and mechanism of Shenqu Xiaoshi oral liquid on gastrointestinal motility in mice with functional dyspepsia

To explore the effect and mechanism of Shenqu Xiaoshi Oral Liquid on gastrointestinal motility in functional dyspepsia (FD) mice...

2022-03-18
【Animal modeling】-Effect of prostacyclin E1 on hepatic fibrosis in rabbits after hepatic arterial lipiodol embolization

【Animal modeling】-Effect of prostacyclin E1 on hepatic fibrosis in rabbits after hepatic arterial lipiodol embolization

To investigate the effect of prostacyclin E1 on the expression levels of Smad2 and Smad4 mRNA in rabbits with hepatic fibrosis after hepatic arterial lipiodol embolization...

2022-03-18
【Animal Modeling】-Exploring the molecular mechanism of resveratrol against myocardial ischemia-reperfusion injury in rats based on network pharmacology

【Animal Modeling】-Exploring the molecular mechanism of resveratrol against myocardial ischemia-reperfusion injury in rats based on network pharmacology

To explore the effect of resveratrol on myocardial ischemia-reperfusion injury in rats and its mechanism of action in rats based on the network pharmacology information screening method...

2022-03-18
【Animal modeling】-The protective effect of piceatannol on brain injury in rats with acute severe carbon monoxide poisoning through MAPK/ERK signaling pathway

【Animal modeling】-The protective effect of piceatannol on brain injury in rats with acute severe carbon monoxide poisoning through MAPK/ERK signaling pathway

To explore the mechanism of piceatannol on brain injury in rats with acute severe carbon monoxide poisoning by regulating MAPK/ERK signaling pathway...

2022-03-18
【Animal modeling】-Effect of alprostadil on eIF2α/ATF4/CHOP pathway and liver function in fulminant liver failure rats

【Animal modeling】-Effect of alprostadil on eIF2α/ATF4/CHOP pathway and liver function in fulminant liver failure rats

To investigate the effect of alprostadil (PGE1) on liver function in rats with fulminant liver failure (FHF), and to investigate its effect on eukaryotic translation initiation factor 2α (eIF2α) / activating transcription factor 4 (ATF4) / C/ EBP Reg...

2022-03-18
【Animal Modeling】-Regulatory effects of corstine on skin inflammation and autophagy in psoriasis mice by inhibiting C5a/C5aR1 pathway

【Animal Modeling】-Regulatory effects of corstine on skin inflammation and autophagy in psoriasis mice by inhibiting C5a/C5aR1 pathway

To investigate the regulatory effect of Cosentyx on skin inflammation and autophagy in psoriatic mice through the C5a/C5aR1 pathway through the imiquimod (IMQ) mouse model of psoriasis...

2022-03-18